HSPA1L Antibody - #DF6662

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产品: HSPA1L 抗体
货号: DF6662
描述: Rabbit polyclonal antibody to HSPA1L
应用: WB IHC IF/ICC
文献验证: IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Dog, Xenopus
蛋白号: P34931
RRID: AB_2838624

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
HSPA1L Antibody detects endogenous levels of total HSPA1L.
RRID:
AB_2838624
引用格式: Affinity Biosciences Cat# DF6662, RRID:AB_2838624.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Heat shock 70 kDa protein 1 Hom; Heat shock 70 kDa protein 1 like; Heat shock 70 kDa protein 1-Hom; Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 1L; Heat shock 70kD protein like 1; HS71L_HUMAN; HSP70 1L; HSP70 HOM; HSP70-Hom; HSPA1L; hum70t; Spermatid specific heat shock protein 70;

抗原和靶标

免疫原:

A synthesized peptide derived from human HSPA1L, corresponding to a region within the internal amino acids.

基因/基因ID:
HSPA1L(3305)
描述:
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Genetic Information Processing > Transcription > Spliceosome.

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Legionellosis.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Influenza A.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Organismal Systems > Aging > Longevity regulating pathway - multiple species.   (View pathway)

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

文献引用

1). VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L. Cell communication and signaling : CCS, 2025 (PubMed: 39875989) [IF=8.4]

Application: IF/ICC    Species: Mouse    Sample:

Fig. 7 The protective effect of VEGFR3 is attenuated in hypertensive mice with HSPA1L-K130R. AAV9 carried with HSPA1L-WT and HSPA1L-K130R were injected the renal pelvis of mice. 2 weeks after AAV9 transfection, these mice were infused with Ang II co-administered with VEGFC via osmotic minipumps. A Systolic BP of the indicated group mice were obtained by the tail-cuff method. B mRNA level of KIM-1 was determined in urine samples of mice. C, D Renal injury was evaluated by CRE and BUN in plasma. E, F HE staining and Masson staining were carried out to assess renal tubular injury, Scale bar, 2–200 μm. G, H The levels of PARKIN, SQSTM1and LC3 II/LC3 I in mitochondria of the renal cortex from each group mice were measured by Immunoblotting. I, J Immunoblotting analysis of 3-nitrotyrosine, 8-oxo-dG, and SOD1 protein expression levels in renal cortex and quantification. K, L Renal tissues were stained to detect MitoSOX Assay Kit (red). Scale bar, 100 μm. M Graphic abstract of the underlying mechanism. n = 5 mice per group. Data in (A) was performed by two-way ANOVA followed by Sidak multiple comparison test. *P 

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