产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6628, RRID:AB_2838590.
展开/折叠
Glandular kallikrein 1; hK 1; hK1; Kallikrein serine protease 1; Kallikrein-1; Kidney/pancreas/salivary gland kallikrein; Klk 6; KLK1; KLK1_HUMAN; Klk6; KLKR; Tissue kallikrein;
抗原和靶标
Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
- P06870 KLK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P06870 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S93 | O-Glycosylation | Uniprot | |
N102 | N-Glycosylation | Uniprot | |
S104 | O-Glycosylation | Uniprot | |
N108 | N-Glycosylation | Uniprot | |
N165 | N-Glycosylation | Uniprot | |
S167 | O-Glycosylation | Uniprot |
研究背景
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In GalNAc was detected with the corresponding peptides but not located.
Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
Belongs to the peptidase S1 family. Kallikrein subfamily.
研究领域
· Organismal Systems > Endocrine system > Renin-angiotensin system. (View pathway)
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
限制条款
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