RGS2 Antibody - #DF6621
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6621, RRID:AB_2838583.
展开/折叠
Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; G0S8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2_HUMAN;
抗原和靶标
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
- P41220 RGS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P41220 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K39 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| T54 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S64 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| K71 | Ubiquitination | Uniprot | |
| K121 | Acetylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot |
研究背景
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Mitochondrion.
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
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