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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6593, RRID:AB_2838555.
展开/折叠
Fc epsilon RI alpha; Fc epsilon RI alpha chain; Fc epsilon RI alpha-chain; Fc fragment of IgE high affinity I receptor for alpha polypeptide; Fc fragment of IgE, high affinity I, receptor for, alpha subunit; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor alpha polypeptide; Fc IgE receptor, alpha chain; Fc IgE receptor, alpha polypeptide; Fc of IgE high affinity I receptor for alpha polypeptide; Fc-epsilon RI-alpha; FCE 1A; FCE1A; FCER 1A; Fcer1a; FCERA_HUMAN; FceRI alpha; FcERI; high affinity IgE receptor; High affinity immunoglobulin epsilon receptor alpha subunit; high affinity immunoglobulin epsilon receptor alpha-subunit; High affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor alpha subunit; IgE Fc receptor subunit alpha; Immunoglobulin E receptor high affinity of mast cells alpha polypeptide; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide;
抗原和靶标
- P12319 FCERA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
翻译修饰 - P12319 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N46 | N-Glycosylation | Uniprot | |
| N67 | N-Glycosylation | Uniprot | |
| N99 | N-Glycosylation | Uniprot | |
| N165 | N-Glycosylation | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| K241 | Acetylation | Uniprot | |
| K251 | Acetylation | Uniprot |
研究背景
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Cell membrane>Single-pass type I membrane protein.
Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
研究领域
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Immune diseases > Asthma.
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
文献引用
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