MTTP Antibody - #DF6591

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产品: MTTP 抗体
货号: DF6591
描述: Rabbit polyclonal antibody to MTTP
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P55157
RRID: AB_2838553

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
MTTP Antibody detects endogenous levels of total MTTP.
RRID:
AB_2838553
引用格式: Affinity Biosciences Cat# DF6591, RRID:AB_2838553.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ABL; Microsomal triglyceride transfer protein (large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer protein large subunit; MTP; MTP large subunit; MTP_HUMAN; MTTP; Transfer RNA, mitochondrial, proline; tRNA-Pro, mitochondrial;

抗原和靶标

免疫原:

A synthesized peptide derived from human MTTP, corresponding to a region within the internal amino acids.

基因/基因ID:
MTTP(4547)
描述:
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

研究领域

· Organismal Systems > Digestive system > Fat digestion and absorption.

文献引用

1). Fucosylated chondroitin sulfate alleviates diet-induced obesity by modulating intestinal lipid metabolism and colonic microflora. International journal of biological macromolecules, 2024 (PubMed: 39521224) [IF=7.7]
2). Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors. Frontiers in immunology, 2025 (PubMed: 40213543) [IF=5.7]

Application: WB    Species: Mouse    Sample: GC cell

Figure 8. Analysis of the clinical relevance of MTTP in GC. Prognostic significance of MTTP in GC by univariate (A) and multifactorial COX analysis (B). (C) Nomogram based on MTTP expression and clinical information. (D) The calibration curve for predicting 1-, 3-, and 5-year OS. (E) t-SNE plot demonstrating 10 clusters from 15 patients with GC (GSE183904). (F) Dot plot showing that MTTP was primarily expressed in malignant tumor cells. (G) The expression of MTTP protein was detected in seven GC cell lines compared with an immortalized gastric cell line (GES-1) and quantified using a gray scale analysis. (H) The representative IHC images of MTTP in GC and adjacent normal tissues ***, P
3). Protective Effect of Patchouli Alcohol Against High-Fat Diet Induced Hepatic Steatosis by Alleviating Endoplasmic Reticulum Stress and Regulating VLDL Metabolism in Rats. Frontiers in Pharmacology, 2019 (PubMed: 31632274) [IF=5.6]

Application: WB    Species: rat    Sample:

FIGURE 7 | PA treatment attenuated HFD-induced MTP reduction in rats. (A) Representative immunoreactive bands of XBP1, PDI, and MTP
4). Caffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway. Bioengineered, 2022 (PubMed: 35481488) [IF=4.2]

Application: WB    Species: mouse    Sample: livers

Figure 5: |CADE regulates lipid synthesis, decomposition and transport through miR-378b in C57BL/6 mice. (a,b) Western blot analysis of the protein expressions of SREBP-1c, FASN, PPARα, CPT1, MTTP and protein ratio of p-foxO1/foxO1 when the mice were injected with AAV-miR-378b agomir and antagomir. All data are expressed as the means ± SD of at least three separate experiments.
5). Androgens exacerbate hepatic triglyceride accumulation in rats with polycystic ovary syndrome by downregulating MTTP expression. Endocrine, 2023 (PubMed: 37950821) [IF=3.0]

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