BMP4 Antibody - #DF6461

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产品: BMP4 抗体
货号: DF6461
描述: Rabbit polyclonal antibody to BMP4
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken
蛋白号: P12644
RRID: AB_2838423

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
BMP4 Antibody detects endogenous levels of total BMP4.
RRID:
AB_2838423
引用格式: Affinity Biosciences Cat# DF6461, RRID:AB_2838423.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

zgc:100779; BMP 2B; BMP 4; BMP-2B; BMP-4; BMP2B; BMP2B1; BMP4; BMP4_HUMAN; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; DVR4; MCOPS6; MGC100779; OFC11; zbmp-4; ZYME;

抗原和靶标

免疫原:

A synthesized peptide derived from human BMP4, corresponding to a region within the internal amino acids.

基因/基因ID:
BMP4(652)
描述:
Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation (1,2). BMPs belongs to the TGF-β superfamily, playing many diverse functions during development (3). BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5 and 8), resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems (3,4).

研究领域

· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells.   (View pathway)

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Basal cell carcinoma.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

文献引用

1). Overexpression of bmp4, dazl, nanos3 and sycp2 in Hu Sheep Leydig Cells Using CRISPR/dcas9 System Promoted Male Germ Cell Related Gene Expression. Biology, 2022 (PubMed: 35205154) [IF=4.2]

Application: WB    Species: sheep    Sample:

Figure 2. The expression levels of bmp4, dazl, nanos3 and sycp2 in sheep testicular development. (A,B) represent the mRNA and protein expression levels of bmp4, dazl, nanos3 and sycp2 in the 3M and 9M group using qPCR and Western blot, respectively. qPCR results were expressed relative to the 3M group as mean values ± the SEM. *** indicates extremely significant differences between groups (p < 0.001); 3M and 9M refer to 3-month-old and 9-month-old testis tissues of sheep, respectively.

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