CD4 Antibody - #DF6451

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产品: CD4 抗体
货号: DF6451
描述: Rabbit polyclonal antibody to CD4
应用: WB
文献验证:
反应: Human, Mouse
预测: Pig, Horse, Rabbit, Dog
蛋白号: P01730
RRID: AB_2838414

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
CD4 Antibody detects endogenous levels of total CD4.
RRID:
AB_2838414
引用格式: Affinity Biosciences Cat# DF6451, RRID:AB_2838414.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD 4; CD4 (L3T4); CD4; CD4 antigen (p55); CD4 antigen; CD4 molecule; CD4 receptor; CD4+ Lymphocyte deficiency, included; CD4_HUMAN; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; MGC165891; OTTHUMP00000238897; p55; T cell antigen T4; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T cell OKT4 deficiency, included; T cell surface antigen T4/Leu 3; T cell surface antigen T4/Leu3; T cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; W3/25; W3/25 antigen;

抗原和靶标

免疫原:

A synthesized peptide derived from human CD4, corresponding to a region within C-terminal amino acids.

基因/基因ID:
CD4(920)
描述:
Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).   (View pathway)

· Human Diseases > Immune diseases > Primary immunodeficiency.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Immune system > Th1 and Th2 cell differentiation.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

· Organismal Systems > Immune system > T cell receptor signaling pathway.   (View pathway)

文献引用

1). Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer. OncoTargets and therapy, 2020 (PubMed: 33173312) [IF=2.7]

Application: IHC    Species: human    Sample:

Figure 1 PD‑L1 and Glut-1 expression, and CD4+, CD8+ T cells infiltration (the black arrows point) in HNSCC at baseline (pre-RT) and after RT (magnification ×400). Positive expression of PD-L1 pre-RT (A) and after RT (B); Positive expression of Glut-1 pre-RT (C) and after RT (D); CD4+ T cells infiltration in tumor tissues pre-RT (E) and after RT (F); CD8+ T cells infiltration in tumor tissues pre-RT (G) and after RT (H).
2). The role of GLUT-1 in upregulation of PD-L1 expression after radiotherapy and PD-L1 is associated with a favourable overall survival in hypopharyngeal cancer. OncoTargets and Therapy, 2020 (PubMed: 33173312) [IF=2.7]

Application: IHC    Species: Human    Sample: tumor tissues

Figure 1 PD-L1 and Glut-1 expression, and CD4+, CD8+ T cells infiltration (the black arrows point) in HNSCC at baseline (pre-RT) and after RT (magnification ×400). Positive expression of PD-L1 pre-RT (A) and after RT (B); Positive expression of Glut-1 pre-RT (C) and after RT (D); CD4+ T cells infiltration in tumor tissues pre-RT (E) and after RT (F); CD8+ T cells infiltration in tumor tissues pre-RT (G) and after RT (H). Abbreviations: GLUT-1, glucose transporter 1; HNSCC, head and neck squamous cell carcinoma; PD-L1, programmed cell death ligand 1; RT, radiotherapy.
3). Zanubrutinib ameliorates experimental idiopathic inflammatory myopathy-associated interstitial lung disease by BTK/NF-κB signaling pathway. Research Square, 2024

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