IGF2BP1 Antibody - #DF6436

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产品: IGF2BP1 抗体
货号: DF6436
描述: Rabbit polyclonal antibody to IGF2BP1
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q9NZI8
RRID: AB_2838399

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
IGF2BP1 Antibody detects endogenous levels of total IGF2BP1.
RRID:
AB_2838399
引用格式: Affinity Biosciences Cat# DF6436, RRID:AB_2838399.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Coding region determinant-binding protein; CRD BP; CRD-BP; CRDBP; IF2B1; IF2B1_HUMAN; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA binding protein 1; IGF2 mRNA-binding protein 1; IGF2BP1; IMP 1; IMP-1; IMP1; Insulin like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; VICKZ family member 1; VICKZ1; ZBP 1; ZBP-1; ZBP1; Zip code binding protein 1; Zip code-binding protein 1; Zipcode binding protein 1; Zipcode-binding protein 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human IGF2BP1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
IGF2BP1(10642)
描述:
Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5).

研究领域

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

文献引用

1). Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways. ENVIRONMENT INTERNATIONAL, 2020 (PubMed: 32388272) [IF=10.3]

Application: WB    Species: Human    Sample: BEAS-2B cells

Fig. 4. The circ_406961 interacts with ILF2 protein. (A) Silver staining image of interaction proteins after circ_406961-pulldown experiment. NC indicates scramble control group; circ_406961 indicates protein group obtained by circ_406961; and Input indicates total protein group (up). Protein expression levels of ILF2, IGF2BP1, IGF2BP2, and IGF2BP3 in circ_406961-pulldown products (down). (B) ILF2, IGF2BP1, IGF2BP2, and IGF2BP3 protein expression levels in si-circ_406961 and PM2.5 co-treated BEAS-2B cells were tested by western blotting. (C) Gray values of ILF2, IGF2BP1, IGF2BP2, and IGF2BP3 protein expression levels. (D) ILF2, IGF2BP1, IGF2BP2, and IGF2BP3 protein expression levels in OE-circ_406961 and PM2.5 co-treated BEAS-2B cells were measured by western blotting. (E) Gray values of ILF2, IGF2BP1, IGF2BP2, and IGF2BP3 protein expression levels. (F) Bioinformatics analysis of interacting region and intensity between circ_406961 and ILF2. (G) Mass spectrogram of ILF2 protein. Data are shown as mean ± SD. *p < 0.05, **p < 0.01 vs control (0 μg/mL PM2.5). #p < 0.05, ##p < 0.01 vs NC (transiently transfected with scrambled sequence) or VEC (transiently transfected with blank plasmid vector).
2). HIF-1α-induced upregulation of m6A reader IGF2BP1 facilitates peripheral nerve injury recovery by enhancing SLC7A11 mRNA stabilization. In vitro cellular & developmental biology. Animal, 2023 (PubMed: 37783915) [IF=1.5]

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