F3 Antibody - #DF6400

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产品: F3 抗体
货号: DF6400
描述: Rabbit polyclonal antibody to F3
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse
蛋白号: P13726
RRID: AB_2838363

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
F3 Antibody detects endogenous levels of total F3.
RRID:
AB_2838363
引用格式: Affinity Biosciences Cat# DF6400, RRID:AB_2838363.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD142; CD142 antigen; Coagulation factor III (thromboplastin tissue factor); Coagulation factor III; F3; FLJ17960; TF; TF_HUMAN; TFA; Thromboplastin; Tissue factor;

抗原和靶标

免疫原:

A synthesized peptide derived from human F3, corresponding to a region within C-terminal amino acids.

基因/基因ID:
F3(2152)
描述:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

研究领域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis. Small (Weinheim an der Bergstrasse, Germany), 2025 (PubMed: 40135385) [IF=13.0]
2). TREM2 improves coagulopathy and lung inflammation in sepsis through the AKT-mTOR pathway. International immunopharmacology, 2025 (PubMed: 39970715) [IF=4.8]
3). Piperlongumin Improves Survival in the Mouse Model of Sepsis: Effect on Coagulation Factors and Lung Inflammation. INFLAMMATION, 2022 (PubMed: 35831643) [IF=4.5]

Application: WB    Species: Mouse    Sample: RAW264.7 cells

Fig. 6 PL reduces the surge in TF and PAI-1 in macrophages stimulated by LPS. A, B Each group was tested using qRT-PCR to detect TF and PAI-1 mRNA levels. C ELISA determined concentrations of PAI-1 in the supernatant of the RAW264.7 cell. D, E Western blot analysis showed protein levels of TF in RAW264.7 cells. F–I AKT, mTOR, and STAT3 phosphorylation was detected by western blot in RAW264.7 cells. Every experiment was repeated three times. Values are indicated as mean ± SD. **P 
4). Pretreatment with Eupatilin Attenuates Inflammation and Coagulation in Sepsis by Suppressing JAK2/STAT3 Signaling Pathway. Journal of Inflammation Research, 2023 (PubMed: 36926276) [IF=4.5]
5). Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells. VASCULAR PHARMACOLOGY, 2021 (PubMed: 33232770) [IF=3.5]
6). Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis. Toxicology and applied pharmacology, 2023 (PubMed: 36621722) [IF=3.3]

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