CYP1B1 Antibody - #DF6399

>>买2送1 进行中>>
>>赠JD卡 进行中>>
(4)   (3)  
产品: CYP1B1 抗体
货号: DF6399
描述: Rabbit polyclonal antibody to CYP1B1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q16678
RRID: AB_2838362

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售
相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CYP1B1 Antibody detects endogenous levels of total CYP1B1.
RRID:
AB_2838362
引用格式: Affinity Biosciences Cat# DF6399, RRID:AB_2838362.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Aryl hydrocarbon hydroxylase; CP1B; CP1B1_HUMAN; Cyp1b1; CYPIB1; Cytochrome P450 1B1; Cytochrome P450 family 1 subfamily B polypeptide 1; Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile); Flavoprotein linked monooxygenase; GLC3A; Microsomal monooxygenase; P4501B1; Xenobiotic monooxygenase;

抗原和靶标

免疫原:

A synthesized peptide derived from human CYP1B1, corresponding to a region within the internal amino acids.

基因/基因ID:
CYP1B1(1545)
描述:
Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function.

研究领域

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

· Metabolism > Amino acid metabolism > Tryptophan metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Organismal Systems > Endocrine system > Ovarian steroidogenesis.

文献引用

1). Multi-omics approaches revealed the therapeutic mechanisms of Suo-Quan-Wan for treating overactive bladder in spontaneously hypertensive rats. Journal of ethnopharmacology, 2024 (PubMed: 37604331) [IF=4.8]
2). Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation. BMC complementary medicine and therapies, 2024 (PubMed: 38849824) [IF=3.3]

Application: WB    Species: Mouse    Sample:

Fig. 6 Experimental validations of HJD treatment against DILI with three identical groups (Control, APAP, and APAP + HJD). (A) and (B) ALT and AST levels (n = 6 animals/group). (C) Representative H&E staining of liver where circled place indicates places of injury, scale bar: 300 μm. (D) Statistics of liver injury area (n = 3 animals/group); (E) Representative western blotting analysis of liver CYP1A1, CYP1A2, and CYP1B1 expression levels in mice liver (n = 3 animals/group), Original images of blots are shown in Fig. S1.; (F) Liver 5-HT level (n = 3 animals/group); (G-H) qRT-PCR analysis of Maoa and Maob in mice liver (n = 3 animals/group). Data are presented as ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with Control group; #, p < 0.05; ##, p < 0.01; ###, p < 0.001 compared with APAP group
3). The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation. BMC Pharmacology and Toxicology, 2022 (PubMed: 35642027) [IF=2.9]
4). Exosomes Derived from Yak Follicular Fluid Increase 2-Hydroxyestradiol Secretion by Activating Autophagy in Cumulus Cells. Animals, 2022 (PubMed: 36428401) [IF=2.7]

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.