产品: CETP 抗体
货号: DF6394
描述: Rabbit polyclonal antibody to CETP
应用: WB IHC IF/ICC
反应: Human, Mouse
分子量: 55kDa; 55kD(Calculated).
蛋白号: P11597
RRID: AB_2838357

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
CETP Antibody detects endogenous levels of total CETP.
RRID:
AB_2838357
引用格式: Affinity Biosciences Cat# DF6394, RRID:AB_2838357.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; HDLCQ10; Lipid transfer protein I;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P11597 CETP_HUMAN:

Expressed by the liver and secreted in plasma.

描述:
Cholesteryl ester transfer protein (CETP) is a circulating metabolic enzyme that transports cholesterol from the arteries to the liver (1-3). CETP converts cholesteryl esters from antiatherogenic high density lipoproteins (HDLs) to proatherogenicapolipoprotein B (apoB)-containing lipoproteins, including very low-, intermediate-, and low-DLs (3). Efficient transfer and exchange of cholesteryl esters and triglycerides between the lipoprotein classes of human plasma is necessary to maintain healthy arteries (4,5).
序列:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

翻译修饰 - P11597 作为底物

Site PTM Type Enzyme
N105 N-Glycosylation
T113 Phosphorylation
N257 N-Glycosylation
S349 Phosphorylation
N358 N-Glycosylation
S400 Phosphorylation
T407 Phosphorylation

研究背景

功能:

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.

细胞定位:

Secreted>Extracellular space.
Note: Secreted in plasma.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed by the liver and secreted in plasma.

蛋白家族:

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

研究领域

· Organismal Systems > Digestive system > Cholesterol metabolism.

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