产品: GSTM2 抗体
货号: DF6339
描述: Rabbit polyclonal antibody to GSTM2
应用: WB IHC
反应: Human, Mouse, Rat
分子量: 26kDa; 26kD(Calculated).
蛋白号: P28161
RRID: AB_2838303

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
GSTM2 Antibody detects endogenous levels of total GSTM2.
RRID:
AB_2838303
引用格式: Affinity Biosciences Cat# DF6339, RRID:AB_2838303.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Glutathione S alkyltransferase M2; Glutathione S aralkyltransferase M2; Glutathione S aryltransferase M2; Glutathione S transferase 4; Glutathione S transferase M1; Glutathione S transferase M2 (muscle); Glutathione S transferase Mu 2 (muscle); Glutathione S transferase Mu 2; Glutathione S-transferase Mu 2; GST class mu 2; GST class-mu 2; GST muscle; GST4; GSTM; GSTM2; GSTM2-2; GSTM2_HUMAN; GTHMUS; MGC117303; S (hydroxyalkyl)glutathione lyase M2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
描述:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
序列:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK

翻译修饰 - P28161 作为底物

Site PTM Type Enzyme
Y23 Phosphorylation
T24 Phosphorylation
S26 Phosphorylation
K31 Ubiquitination
K32 Ubiquitination
R43 Methylation
K50 Ubiquitination
T67 Phosphorylation
K69 Ubiquitination
T71 Phosphorylation
R78 Methylation
K144 Acetylation
S186 Phosphorylation
K193 Ubiquitination
K199 Acetylation
K199 Ubiquitination
S200 Phosphorylation
S201 Phosphorylation
K218 Ubiquitination

研究背景

功能:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Muscle.

亚基结构:

Homodimer.

蛋白家族:

Belongs to the GST superfamily. Mu family.

研究领域

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Metabolism > Metabolism of other amino acids > Glutathione metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.

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