CYR61/CCN1 Antibody - #DF6250

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产品: CYR61/CCN1 抗体
货号: DF6250
描述: Rabbit polyclonal antibody to CYR61/CCN1
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Rabbit
蛋白号: O00622
RRID: AB_2838216

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CYR61/CCN1 Antibody detects endogenous levels of total CYR61/CCN1.
RRID:
AB_2838216
引用格式: Affinity Biosciences Cat# DF6250, RRID:AB_2838216.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

3CH61; CCN 1; CCN family member 1; CYR 61; Cyr61; CYR61 protein; CYR61_HUMAN; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; Cysteine-rich angiogenic inducer 61; GIG 1; GIG1; IBP-10; IGF-binding protein 10; Igfbp 10; IGFBP-10; Igfbp10; Insulin like growth factor binding protein 10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1;

抗原和靶标

免疫原:

A synthesized peptide derived from human CYR61/CCN1, corresponding to a region within the internal amino acids.

基因/基因ID:
CYR61(3491)
描述:
Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. Cyr61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse Cyr61 homolog, Fisp12. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation. Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

文献引用

1). Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer. Gastric Cancer, 2019 (PubMed: 30178386) [IF=6.0]

Application: IHC    Species: human    Sample: gastric and GC tissues

Fig. 5| High expression of CYR61 was associated with prognosis in GC. a The expression of CYR61 in normal gastric tissues (upper) and GC tissues (lower) (left: magnification ×200; right: magnification ×400).

Application: WB    Species: human    Sample: BGC823 and SGC7901 cells， AGS cells

Fig. 3 |CYR61 is a novel target gene of miR-142-5p. c Left and middle, qRT-PCR and western blot showed that the expression of CYR61 was significantly decreased in miR-142-5p-stably transfected BGC823 and SGC7901 cells as compared with control cells. Right, qRT-PCR and western blot showed that the expression of CYR61 was significantly increased in miR142-5p-inhibitor-stably transfected AGS cells as compared with control cells. *P < 0.05, **P < 0.01, ***P < 0.001.
2). CYR61 is Involved in Neonatal Hypoxic-ischemic Brain Damage Via Modulating Astrocyte-mediated Neuroinflammation. Neuroscience, 2024 (PubMed: 38908506) [IF=2.9]
3). Upregulation of Angiomotin-like 2 ameliorates experimental pulmonary arterial hypertension by inactivating YAP1 signaling. Journal of cardiovascular pharmacology, 2022 (PubMed: 39027975) [IF=2.6]

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