CUL3 Antibody - #DF6223

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产品: CUL3 抗体
货号: DF6223
描述: Rabbit polyclonal antibody to CUL3
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: Q13618
RRID: AB_2838189

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CUL3 Antibody detects endogenous levels of total CUL3.
RRID:
AB_2838189
引用格式: Affinity Biosciences Cat# DF6223, RRID:AB_2838189.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CUL 3; Cul-3; cul3; CUL3_HUMAN; Cullin-3; Cullin3; KIAA0617; PHA2E;

抗原和靶标

免疫原:

A synthesized peptide derived from human CUL3, corresponding to a region within the internal amino acids.

基因/基因ID:
CUL3(8452)
描述:
CUL3 (Cullin-3) is a member of the cullin-based ubiquitin ligase family. By interacting with Hrt1 and BTB domain containing proteins, the complex functions as a CUL3-based E3 ligase to bring specific substrates to ubiquitinylation and degradation (1). The CUL3 complex has been shown to target many substrates involved in cell cycle progression (2), transcription (3), development and differentiation (4,5).

研究领域

· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

文献引用

1). Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer. Chemico-Biological Interactions, 2023 (PubMed: 36736873) [IF=4.7]
2). Bioinformatics analysis identifies potential hub genes and crucial pathways in the pathogenesis of asthenozoospermia. BMC Medical Genomics, 2022 (PubMed: 36471356) [IF=2.7]

Application: WB    Species: Human    Sample: normozoospermia and asthenozoospermia samples

Fig. 9 Hub genes expression in normozoospermia and asthenozoospermia samples A Expressions of four hub genes were validated by qRT-PCR in spermatozoa from normozoospermia and asthenozoospermia. B Expressions of four hub genes were validated by western blotting experiments in spermatozoa from normozoospermia and asthenozoospermia. *P 

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