BIRC2 Antibody - #DF6167

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产品: BIRC2 抗体
货号: DF6167
描述: Rabbit polyclonal antibody to BIRC2
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q13490
RRID: AB_2838134

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:400
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
BIRC2 Antibody detects endogenous levels of total BIRC2.
RRID:
AB_2838134
引用格式: Affinity Biosciences Cat# DF6167, RRID:AB_2838134.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

API 1; API1; Apoptosis inhibitor 1; Baculoviral IAP repeat containing 2; Baculoviral IAP repeat containing protein 2; Baculoviral IAP repeat-containing protein 2; BIRC 2; BIRC2; BIRC2_HUMAN; C IAP1; C-IAP1; cIAP 1; cIAP1; HIAP 2; HIAP-2; HIAP2; IAP 2; IAP homolog B; IAP-2; IAP2; Inhibitor of apoptosis protein 2; MIHB; NFR2 TRAF signalling complex protein; RING finger protein 48; RNF 48; RNF48; TNFR2 TRAF signaling complex protein 2; TNFR2-TRAF-signaling complex protein 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human BIRC2, corresponding to a region within C-terminal amino acids.

基因/基因ID:
BIRC2(329)
描述:
The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

研究领域

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis - multiple species.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). TRAIL‐Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582). Advanced Healthcare Materials, 2021 (PubMed: 33963815) [IF=10.0]
2). YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis. Journal of orthopaedic translation, 2024 (PubMed: 38817242) [IF=5.9]
3). Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles. Heliyon, 2024 (PubMed: 38596136) [IF=4.0]

Application: IHC    Species: human    Sample:

Fig. 3 Expression Analysis of sEV cargo marker proteins. Western blot profiling and densitometric analysis of (A) BIRC2/cIAP1 (p = 0.002, 0.0157); and (B) Beclin-1(p = 0.0248) in all three categories control (C1, C2) and PanNETs patients [Grade 1 (GA1, GA2) & 2 (GB1, GB2)]. Immunohistochemical expression of BIRC2/cIAP1 and Beclin-1 in controls (C & F, respectively), the red box shows the islet of Langerhans. Immunohistochemical expression of BIRC2/cIAP1 and Beclin-1 in Grade 1 (D & G, respectively) & Grade 2 (E & H, respectively), and the red boxes show tumor sites at the islet of Langerhans in PanNET patients. The scale bar is 25 μm.
4). HIF-1 α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma. International journal of dentistry, 2021 (PubMed: 34987583) [IF=1.9]

Application: IHC    Species: Human    Sample: Ameloblastoma

Figure 2 Immunomarking for HIF-1α, IAP-2, GLUT1, and Bcl-2 in AMB and FP. HIF-1α staining in AMB (a) was nuclear in the solid tumour area (arrowheads) and cytoplasmic and nuclear in cells near the cystic areas of the epithelial islets (arrow and cystic lumen, ∗). IAP-2 labelling on AMB (c) was predominant in the cytoplasm and nucleus (arrow) of the cells of the epithelial islands. Marking is also detected in selected cells from the basal and central layers (arrowhead and arrow, resp.). GLUT1 immunostaining in AMB (e) is predominant in the cytoplasm of the cells of the basal and central layer of the epithelial islands (arrowhead and arrow, resp.). Bcl-2 immunostaining in AMB (g) is predominant in the cytoplasm of epithelial island cells (arrow). Marking is also detected in selected cells from the basal and central layers (arrowhead and arrow, resp.). The FP shows a weaker labelling of the proteins IAP-2, GLUT1, and Bcl-2 compared with AMB (b, d, f, h). Scale 100 and 20 μm. Comparison of immunoexpression of the HIF-1α, IAP-2, GLUT1 and Bcl-2, and HIF-1α in the ameloblastoma (a) and the follicle dental (f). ∗∗∗p < 0.001 (m).
5). Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritis. Research Square, 2022

Application: WB    Species: Human    Sample: CSPCs

Figure 7. Transcriptomic analysis. a KEGG and GO enrichment analysis of DEGs. b The detailed DEGs that enriched in cell cycle, cellular senescence, autophagy, apoptosis, Hippo signaling pathway, and TNF signaling pathways. c The direct downstream target genes of YAP. d The protein level of Birc2, Snai2, Zenb2, and Ccnd2 in CSPCs.

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