VDAC1 Antibody - #AF5478

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产品: VDAC1 抗体
货号: AF5478
描述: Rabbit polyclonal antibody to VDAC1
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白ID: P21796
RRID: AB_2837960

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VDAC1 Peptide

1mg
相关下载
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
VDAC1 Antibody detects endogenous levels of total VDAC1.
RRID:
AB_2837960
引用格式: Affinity Biosciences Cat# AF5478, RRID:AB_2837960.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

N2441; OMP2; POR1; hVDAC1; MGC111064; Mitochondrial Porin; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; VDAC; VDAC-1; Vdac1; VDAC1_HUMAN; Voltage dependent anion channel 1; Voltage dependent anion selective channel protein 1; Voltage-dependent anion-selective channel protein 1; YNL055C; YNL2441C;

抗原和靶标

免疫原:

A synthesized peptide derived from human VDAC1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
VDAC1(7416)
描述:
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Infectious diseases: Viral > Influenza A.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Cholesterol metabolism.

文献引用

1). The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan. Acta pharmaceutica Sinica. B, 2024 (PubMed: 39027239) [IF=14.7]
2). VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L. Cell communication and signaling : CCS, 2025 (PubMed: 39875989) [IF=8.4]

Application: WB    Species: Mouse    Sample:

Fig. 2 Activation of VEGFR3 decreases renal oxidative stress levels and restored mitophagy in Ang II-induced hypertensive mice. A Significant statistics of GO term enrichment analysis (Control versus Ang II). B, C Renal tissues were stained to detect MitoSox Assay Kit (red). Scale bar, 100 μm. D Expressions of SQSTM1 and LC3 II/LC3 I were determined in mitochondria of the renal cortex from each group mice. E 3-nitrotyrosine, 8-oxo-dG, and SOD1 protein expression levels in renal cortex were examined by immunoblotting. F, G Immunoblots were statistically quantified by densitometry. H, I HE and Masson staining were carried out to assess the degree of renal tubular injury and fibrosis. J, K Semiquantitative scoring of tubular injury and renal fibrosis in different groups. Scale bar, 2–200 μm. n = 5 mice per group. Data in (B-K) were analyzed with one-way ANOVA. **P 
3). Glucocorticoids-Driven Mitochondrial GR Translocation Promotes Heat Stress-Induced Mastitis via the mtDNA-cGAS-STING-NF-κB/NLRP3 Pathway. FREE RADICAL BIOLOGY AND MEDICINE, 2026 [IF=8.0]
4). Zinc protects against neuroinflammation after spinal cord injury by regulating mitophagy-dependent mtDNA-cGAS-STING signaling. Free radical biology & medicine, 2026 (PubMed: 41672114) [IF=7.1]
5). Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells. British journal of pharmacology, 2023 (PubMed: 36740831) [IF=6.8]
6). MARCH5-mediated MIEF2 ubiquitination and degradation contribute to gigantol to against hepatic steatosis and mitochondrial fission in alcoholic liver disease. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025 (PubMed: 41353882) [IF=6.7]
7). Cyfluthrin exposure during pregnancy causes neurotoxicity in offspring-Ca2+ overload via IP3R-GRP75-VDAC1 pathway. Ecotoxicology and environmental safety, 2024 (PubMed: 38492481) [IF=6.2]
8). Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells. iScience, 2024 (PubMed: 39759022) [IF=5.8]
9). Methylseleninic Acid Elevating the Nrf2-GPX4 Axis Relieves Endothelial Dysfunction and Ferroptosis Induced by Arsenic Exposure. Journal of agricultural and food chemistry, 2025 (PubMed: 40071728) [IF=5.7]
10). 3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2. Journal of Agricultural and Food Chemistry, 2023 (PubMed: 37750480) [IF=5.7]
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