Desmin Antibody - #AF5334

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产品: Desmin 抗体
货号: AF5334
描述: Rabbit polyclonal antibody to Desmin
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat, Monkey
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: P17661
RRID: AB_2837819

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat, Monkey
克隆:
Polyclonal
特异性:
Desmin Antibody detects endogenous levels of total Desmin.
RRID:
AB_2837819
引用格式: Affinity Biosciences Cat# AF5334, RRID:AB_2837819.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CMD1I; CSM1; CSM2; DES; DESM_HUMAN; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793; Intermediate filament protein; OTTHUMP00000064865;

抗原和靶标

免疫原:

A synthesized peptide derived from human Desmin, corresponding to a region within C-terminal amino acids.

基因/基因ID:
DES(1674)
描述:
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

研究领域

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).

文献引用

1). Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. Stem Cell Research & Therapy, 2022 (PubMed: 36064453) [IF=7.5]
2). Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy. Acta Pharmacologica Sinica, 2023 (PubMed: 37596398) [IF=6.9]
3). Exosomes derived from smooth muscle cells ameliorate diabetes‐induced erectile dysfunction by inhibiting fibrosis and modulating the NO/cGMP pathway. Journal of Cellular and Molecular Medicine, 2020 (PubMed: 33009701) [IF=5.3]

Application: IF/ICC    Species: rat    Sample: CCSMCs

FIGURE 1 |Cell identification and exosome characterization. (C) Representative immunofluorescence results of CCSMCs show positive expression for α-SMA and desmin. Scale bars = 50 μm
4). Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration. Disease Models & Mechanisms, 2021 (PubMed: 34821368) [IF=4.0]
5). The potential role of differentially expressed tRNA-derived fragments in high glucose-induced podocytes. Renal failure, 2024 (PubMed: 38369750) [IF=3.0]

Application: WB    Species: Mouse    Sample:

Figure 1. Construction of the podocyte injury model. (A) RT-qPCR was used to measure the mRNA expression levels of nephrin, podocin and desmin in mouse podocytes in the control, HG, and mannitol groups. (B) Protein expression levels of related indexes in cells were assessed by western blotting. The data are expressed as the mean ± SD. *p < .05, ***p < .001 vs. the control group. NS: not significant; HG: high glucose; RT-qPCR: real-time quantitative polymerase chain reaction.
6). Integrated Network Pharmacology and Cellular Assay to Explore the Mechanisms of Selenized Tripterine Phytosomes (Se@Tri-PTs) Alleviating Podocyte Injury in Diabetic Nephropathy. Current pharmaceutical design, 2023 (PubMed: 37961864) [IF=2.6]

Application: WB    Species: Mouse    Sample: podocytes

Fig. (7). Expressions of nephrin and desmin in podocytes treated for 48 h and quantified by western blot. **P < 0.01, compared to the NG group. Abbreviations: NG, normal glucose; DM, D-mannitol (30 mmol/L); HG, high glucose (30 mmol/L). (A higher resolution/colour version of this figure is available in the electronic copy of the article).
7). Berberine and Glycyrrhizic Acid Co-Assembled Nanoparticles Mitigate Podocyte Injury Via Suppressing Ferroptosis. , 2024

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