TRP2/DCT Antibody - #AF5303

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产品: TRP2/DCT 抗体
货号: AF5303
描述: Rabbit polyclonal antibody to TRP2/DCT
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P40126
RRID: AB_2837788

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TRP2/DCT Antibody detects endogenous levels of total TRP2/DCT.
RRID:
AB_2837788
引用格式: Affinity Biosciences Cat# AF5303, RRID:AB_2837788.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

L dopachrome tautomerase; DCT; Dopachrome delta isomerase; Dopachrome tautomerase; Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2; DT; EC 5.3.3.12; L dopachrome Delta isomerase; L-dopachrome Delta-isomerase; L-dopachrome tautomerase; TRP 2; TRP-2; TRP2; Tyrosinase related protein 2; Tyrosinase-related protein 2; TYRP2; TYRP2_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human TRP2/DCT, corresponding to a region within N-terminal amino acids.

基因/基因ID:
DCT(1638)
描述:
Involved in regulating eumelanin and phaeomelanin levels.PathwayPigment biosynthesis; melanin biosynthesis.

研究领域

· Metabolism > Amino acid metabolism > Tyrosine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > Melanogenesis.

文献引用

1). The critical role of ROS in Ermanin-induced melanogenesis. Free radical biology & medicine, 2021 (PubMed: 34560247) [IF=7.1]
2). Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway. Frontiers in pharmacology, 2025 (PubMed: 40129935) [IF=5.6]

Application: WB    Species: Mouse    Sample: B16F10 cells

Figure 8. Effect of GA on the expression of key signaling pathway proteins. (A) Western blotting to detect the expression levels of p38 MAPK, ERK and JNK. (B–D) Effect of GA on the expression of p38, JNK1/2/3 and ERK1/2 proteins in B16F10 cells (n = 3). (E) Western blotting to detect the expression levels of MITF, TYR, TRP2 and TRP1. (F–I) Effect of GA on MITF, TYR, TRP2 and TRP1 protein expression in B16F10 cells (n = 3).
3). Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits. Animal bioscience, 2025 (PubMed: 39210791) [IF=2.4]

Application: IF/ICC    Species: Mouse    Sample:

Figure 2. Isolation and identification of melanocytes. (a) Immunofluorescence staining of MC-specific markers MITF, TYRP2, and TYR. (b) MC identification through L-DOPA reactivity. (c) Western blot analysis of TYR and MITF proteins in MCs. MC, melanocytes; MITF, microphthalmia-associated transcription factor; TYRP2, tyrosinase-related protein 2; TYR, tyrosinase, L-DOPA, L-3,4-dihydroxyphenylalanine.

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