TRP2/DCT Antibody - #AF5303

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产品: TRP2/DCT 抗体
货号: AF5303
描述: Rabbit polyclonal antibody to TRP2/DCT
应用: WB IHC IF/ICC
文献验证: IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P40126
RRID: AB_2837788

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TRP2/DCT Antibody detects endogenous levels of total TRP2/DCT.
RRID:
AB_2837788
引用格式: Affinity Biosciences Cat# AF5303, RRID:AB_2837788.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

L dopachrome tautomerase; DCT; Dopachrome delta isomerase; Dopachrome tautomerase; Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2; DT; EC 5.3.3.12; L dopachrome Delta isomerase; L-dopachrome Delta-isomerase; L-dopachrome tautomerase; TRP 2; TRP-2; TRP2; Tyrosinase related protein 2; Tyrosinase-related protein 2; TYRP2; TYRP2_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human TRP2/DCT, corresponding to a region within N-terminal amino acids.

基因/基因ID:
DCT(1638)
描述:
Involved in regulating eumelanin and phaeomelanin levels.PathwayPigment biosynthesis; melanin biosynthesis.

研究领域

· Metabolism > Amino acid metabolism > Tyrosine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > Melanogenesis.

文献引用

1). The critical role of ROS in Ermanin-induced melanogenesis. Free radical biology & medicine, 2021 (PubMed: 34560247) [IF=7.1]
2). Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway. Frontiers in pharmacology, 2025 (PubMed: 40129935) [IF=5.6]
3). Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits. Animal bioscience, 2025 (PubMed: 39210791) [IF=2.4]

Application: IF/ICC    Species: Mouse    Sample:

Figure 2. Isolation and identification of melanocytes. (a) Immunofluorescence staining of MC-specific markers MITF, TYRP2, and TYR. (b) MC identification through L-DOPA reactivity. (c) Western blot analysis of TYR and MITF proteins in MCs. MC, melanocytes; MITF, microphthalmia-associated transcription factor; TYRP2, tyrosinase-related protein 2; TYR, tyrosinase, L-DOPA, L-3,4-dihydroxyphenylalanine.

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