CMKLR1 Antibody - #AF5291

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产品: CMKLR1 抗体
货号: AF5291
描述: Rabbit polyclonal antibody to CMKLR1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q99788
RRID: AB_2837776

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CMKLR1 Antibody detects endogenous levels of total CMKLR1.
RRID:
AB_2837776
引用格式: Affinity Biosciences Cat# AF5291, RRID:AB_2837776.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CHEMERINR; Chemokine like receptor 1; Chemokine-like receptor 1; CHEMR23; CMKLR1; CML1_HUMAN; DEZ; G protein coupled receptor ChemR23; G protein coupled receptor DEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; Orphan G protein coupled receptor; Orphan G protein coupled receptor Dez; Resolvin E1 receptor; RVER1;

抗原和靶标

免疫原:

A synthesized peptide derived from human CMKLR1, corresponding to a region within the internal amino acids.

基因/基因ID:
CMKLR1(1240)
描述:
Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

文献引用

1). Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin/CMKLR1 signalling pathway and Treg/Th17 ratio. Naunyn-Schmiedeberg's archives of pharmacology, 2021 (PubMed: 32524150) [IF=3.1]

Application: WB    Species: rat    Sample: liver

Fig. 2| Berberine regulates intrahepatic chemerin/CMKLR1 pathway. a–c The protein levels of chemerin and CMRKL1 were measured by Western blot analysis and normalized by GAPDH Expression.
2). α-NETA down-regulates CMKLR1 mRNA expression in ileum and prevents body weight gains collaborating with ERK inhibitor PD98059 in turn to alleviate hepatic steatosis in HFD-induced obese mice but no impact on ileal mucosal integrity and steatohepatitis progression. BMC endocrine disorders, 2023 (PubMed: 36624417) [IF=2.7]
3). Chemerin promotes the viability and migration of human placental microvascular endothelial cells and activates MAPK/AKT signaling . International Journal of Clinical and Experimental Medicine, 2018 [IF=0.2]

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