GPR120 Antibody - #AF5219

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产品: GPR120 抗体
货号: AF5219
描述: Rabbit polyclonal antibody to GPR120
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q5NUL3
RRID: AB_2837705

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
GPR120 Antibody detects endogenous levels of total GPR120.
RRID:
AB_2837705
引用格式: Affinity Biosciences Cat# AF5219, RRID:AB_2837705.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

G protein coupled receptor 120; G protein coupled receptor 129; G protein coupled receptor GT01; G protein coupled receptor PGR 4; G protein coupled receptor PGR4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPR 120; GPR 129; GPR120; GPR129; GT01; HGNC:19345; MGC119984; O3FA1_HUMAN; O3FAR1; Omega-3 fatty acid receptor 1; PGR 4; PGR4;

抗原和靶标

免疫原:

A synthesized peptide derived from human GPR120, corresponding to a region within the internal amino acids.

基因/基因ID:
FFAR4(338557)
描述:
GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source

文献引用

1). GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization. Journal of hazardous materials, 2024 (PubMed: 39709819) [IF=13.6]
2). Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO reports, 2024 (PubMed: 39482491) [IF=6.5]

Application: WB    Species: Mouse    Sample: RAW264.7 cells

Figure 8. EPA activated HO-1 expression via GPR120 in M1 polarized macrophages. (A) Protein levels of GPR120. †P = 0.018, LPS + EPA vs. LPS + DMSO. Analysis by one-way ANOVA. (B) To verify the efficacy of AH7614, protein level of GPR120 was determined in RAW264.7 cells. *P = 0.023, LPS + AH7614 vs. LPS + DMSO. Analysis by two-tailed unpaired Student’s t-test. (C, D) To study the effect of GPR120 in the maintenance of EPA’s elevation of HO-1, protein levels of GPR120 and HO-1 were measured in RAW264.7 cells. For (C), **P = 0.001, LPS + EPA vs. LPS + DMSO; †††P 
3). Loureirin B Reduces Insulin Resistance and Chronic Inflammation in a Rat Model of Polycystic Ovary Syndrome by Upregulating GPR120 and Activating the LKB1/AMPK Signaling Pathway. International journal of molecular sciences, 2024 (PubMed: 39456928) [IF=5.6]

Application: WB    Species: Rat    Sample:

Figure 10. Effects of LrB on GPR120 expression in PCOS-IR rat ovaries. Data are means ± SDs; n = 3. (A) Western blot analysis of GPR120 and GAPDH in ovarian tissues at four weeks of treatment. (B) Quantitative analysis of GPR120 levels in ovarian tissues at four weeks of treatment. (C) Expression levels of GPR120 mRNA in ovarian tissues at four weeks of treatment. Relative to the normal group, ## p < 0.01; relative to the PCOS-IR group
4). Different n-6/n-3 PUFA diets with fish oil attenuated osteoarthritis in ovariectomized mice via targeting the NLRP3 inflammasome. Food Bioscience, 2022 [IF=4.8]
5). Stearic acid induces CCK and GLP-1 upregulation via GPR120/PLC-β, leading to reduced appetite in Hu sheep fed with rice straw. Frontiers in veterinary science, 2022 (PubMed: 36118346) [IF=3.2]

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