Cytochrome P450 17A1 Antibody - #AF5210

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产品: Cytochrome P450 17A1 抗体
货号: AF5210
描述: Rabbit polyclonal antibody to Cytochrome P450 17A1
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Rabbit, Dog
蛋白号: P05093
RRID: AB_2837696

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Cytochrome P450 17A1 Antibody detects endogenous levels of total Cytochrome P450 17A1.
RRID:
AB_2837696
引用格式: Affinity Biosciences Cat# AF5210, RRID:AB_2837696.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase;

抗原和靶标

免疫原:

A synthesized peptide derived from human Cytochrome P450 17A1, corresponding to a region within the internal amino acids.

基因/基因ID:
CYP17A1(1586)
描述:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

研究领域

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > Ovarian steroidogenesis.

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

文献引用

1). The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3. Frontiers in Pharmacology, 2020 (PubMed: 32457626) [IF=5.6]

Application: WB    Species: mouse    Sample: LC540 (17b-HSD3) cells

FIGURE 3 | Effects of H10 on 17b-HSD3 in LC540 (17b-HSD3) cells. Effects of H10 on the production of (A) T and (B) P. (C) The expression of 17b-HSD3 mRNA.(D) The expression levels of the proteins in the T synthesis pathway were detected by western blotting following treatment with H10. The concentrations of H10 were 0.25, 0.5, and 1 mM, while the concentration of 3858858 (positive control) was 0.25 mM.
2). CIRBP Enhances the Function of Yak Cumulus Cells by Activating AMPK/mTOR-Mediated Mitophagy. Biomolecules, 2025 (PubMed: 40563401) [IF=5.5]
3). CIRBP Increases the synthesis and secretion of steroid hormones by in yak granulaso cells. The Journal of steroid biochemistry and molecular biology, 2024 (PubMed: 38143009) [IF=2.7]
4). Exosomes Derived from Yak Follicular Fluid Increase 2-Hydroxyestradiol Secretion by Activating Autophagy in Cumulus Cells. Animals, 2022 (PubMed: 36428401) [IF=2.7]
5). Mechanism of cadmium poisoning on testicular injury in mice. Oncology Letters, 2019 (PubMed: 31423163) [IF=2.5]

Application: IHC    Species: mouse    Sample: testicular

Figure 3.| Influence of cadmium on testicular tissue protein levels and apoptosis of testicular cells. (A) H&E staining revealed testicular morphology. Immunohistochemical staining demonstrated that the testicular morphology and expression levels of LHR, 17α‑hydroxylase and eNOS were altered in testicular tissues following administration of different concentrations of cadmium. Magnification, x400.

Application: WB    Species: mouse    Sample: testicular

Figure 4.| Influence of cadmium on Leydig cell protein expression levels determined by western blotting. (A) Expression levels of LHR, 17α‑hydroxylase and eNOS were altered in testicular tissues following administration of different concentrations of cadmium.
6). The co-expression of steroidogenic enzymes with T1R3 during testicular development in the Congjiang Xiang pig. Animal reproduction science, 2023 (PubMed: 37011421) [IF=2.2]

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