APOE Antibody - #AF5178

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产品: APOE 抗体
货号: AF5178
描述: Rabbit polyclonal antibody to APOE
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Rabbit
蛋白号: P02649
RRID: AB_2837664

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
APOE Antibody detects endogenous levels of total APOE.
RRID:
AB_2837664
引用格式: Affinity Biosciences Cat# AF5178, RRID:AB_2837664.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AD2; Apo-E; APOE; APOE_HUMAN; APOEA; Apolipoprotein E; Apolipoprotein E3; ApolipoproteinE; Apoprotein; LDLCQ5; LPG;

抗原和靶标

免疫原:

A synthesized peptide derived from human APOE, corresponding to a region within the internal amino acids.

基因/基因ID:
APOE(348)
描述:
Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

研究领域

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Organismal Systems > Digestive system > Cholesterol metabolism.

文献引用

1). Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer. NPJ precision oncology, 2025 (PubMed: 41298873) [IF=7.9]

Application: IF/ICC    Species: human    Sample:

Fig. 5: Cell-to-cell communications among thyrocyte and immune cells predicted by the CellChat software in PTC and ATC. A Circle plot summarizing the maximum number of interactions among individual cell types in PTC. The thickness of the lines connecting cells indicates the interaction strength. B The same plot as in (A) but applied to ATC. C Differences of number and strength overall information flow within the inferred networks between PTC and ATC. D The potential outgoing and incoming interaction strength of each cellular cluster in PTC and ATC. Heatmap showing the relative signaling contribution of each cell group based on the number and strength compared PTC with ATC. E Heatmap showing the relative signaling contribution of each cell group based on the number and strength compared PTC with ATC. F Differential strength of network centrality based on APOE+ macrophages (PTC vs. ATC). G Bubble heatmap showing the cell–cell communication of selected ligand–receptor pairs between APOE+ macrophage and CD8+ PDCD1+ T cells. Dot size indicates P value, colored by communication probability. H Multiplex IHC shows the cross-talk between APOE+ macrophages and T cells via the ligand–receptor of THBS1-CD47.
2). Proteomics Reveals the Key Molecules Involved in Curcumin-induced Protection Against Sciatic Nerve Injury in Rats. NEUROSCIENCE, 2022 (PubMed: 35870565) [IF=2.9]
3). The protective effect of magnesium sulfate on placental inflammation via suppressing the NF-κB pathway in a preeclampsia-like rat model. Pregnancy Hypertension, 2023 (PubMed: 36435037) [IF=2.5]
4). Stress causes cognitive impairment by affecting cholesterol efflux and reuptake leading to abnormalities in lipid metabolism of rats. Journal of integrative neuroscience, 2020 (PubMed: 32259885)

Application: WB    Species: rat    Sample: hippocampus

Figure 7. |The levels of efflux and reuptake proteins of cholesterol in CUMS rats. (A) The expression of ABCA1, LRP1, and ApoE in control and CUMS rats in the sixth week of the CUMS period.

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