PAI 1 Antibody - #AF5176

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产品: PAI 1 抗体
货号: AF5176
描述: Rabbit polyclonal antibody to PAI 1
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P05121
RRID: AB_2837662

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
PAI 1 Antibody detects endogenous levels of total PAI 1.
RRID:
AB_2837662
引用格式: Affinity Biosciences Cat# AF5176, RRID:AB_2837662.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin E1; Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin peptidase inhibitor clade E; Serpine 1; SERPINE1;

抗原和靶标

免疫原:

A synthesized peptide derived from human PAI 1, corresponding to a region within the internal amino acids.

基因/基因ID:
SERPINE1(5054)
描述:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

研究领域

· Cellular Processes > Cell growth and death > p53 signaling pathway.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Tumor Microenvironment Heterogeneity-Based Score System Predicts Clinical Prognosis and Response to Immune Checkpoint Blockade in Multiple Colorectal Cancer Cohorts. Frontiers in molecular biosciences, 2022 (PubMed: 35836930) [IF=5.0]
2). Effects of (Pro) renin Receptor on Diabetic Cardiomyopathy Pathological Processes in Rats via the PRR-AMPK-YAP Pathway. Frontiers in Physiology, 2021 (PubMed: 34122131) [IF=4.0]

Application: IHC    Species: Human    Sample: mesangial cells

FIGURE 2 PRR silencing decreased myocardial interstitial fibrosis and inflammation in rats with diabetic cardiomyopathy (n = 5). (A–F) Representative immunohistochemical staining of Collagen I, Fibronectin, PAI-1, TGF-β, IL-1β and IL-18 in the 4 groups (scale bar = 20 μm). (G–L) Quantitative analysis of the Collagen I, Fibronectin, PAI-1, TGF-β, IL-1β, and IL-18 protein expression shown in panels (A–F). *p < 0.05 versus the control group; #p < 0.05 versus the Ad-SC-shRNA group.
3). Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis. Naunyn-Schmiedeberg's archives of pharmacology, 2024 (PubMed: 38133657) [IF=3.1]
4). Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis. Naunyn-Schmiedeberg's archives of pharmacology, 2024 (PubMed: 38133657) [IF=3.1]
5). Yes-Associated Protein is Involved in Myocardial Fibrosis in Rats with Diabetic Cardiomyopathy. Diabetes, Metabolic Syndrome and Obesity, 2021 (PubMed: 34012279) [IF=2.8]

Application: IHC    Species: Rat    Sample: myocardium

Figure 2 HE staining, CTGF, Profilin-1, and PAI-1 protein expression in the myocardium in vivo (n=6). (A-D) Representative HE staining and immunohistochemical staining of CTGF, Profilin-1 and PAI-1 in the 4 groups (scale bar=20 μm). (E-H) Quantitative analysis of CTGF, Profilin-1, and PAI-1 protein expression.
6). TGF-β1-Mediated Activation of SERPINE1 is Involved in Hemin-Induced Apoptotic and Inflammatory Injury in HT22 Cells. Neuropsychiatric Disease and Treatment, 2021 (PubMed: 33603380) [IF=2.5]

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