SOD2/MnSOD Antibody - #AF5144

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产品: SOD2/MnSOD 抗体
货号: AF5144
描述: Rabbit polyclonal antibody to SOD2/MnSOD
应用: WB IHC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Xenopus
蛋白号: P04179
RRID: AB_2837630

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SOD2/MnSOD Antibody detects endogenous levels of total SOD2/MnSOD.
RRID:
AB_2837630
引用格式: Affinity Biosciences Cat# AF5144, RRID:AB_2837630.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial;

抗原和靶标

免疫原:

A synthesized peptide derived from human SOD2/MnSOD, corresponding to a region within the internal amino acids.

基因/基因ID:
SOD2(6648)
描述:
Mn SOD antibody Mn superoxide dismutase antibody MNSOD antibody MVCD6 antibody SOD 2 antibody SOD2 antibody SODM_HUMAN antibody

研究领域

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway - multiple species.   (View pathway)

文献引用

1). Catalytic Nanodots-Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration. Advanced materials (Deerfield Beach, Fla.), 2024 (PubMed: 38299823) [IF=27.4]
2). Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling. Free radical biology & medicine, 2021 (PubMed: 34648904) [IF=7.1]
3). Aqueous extract of Phellinus igniarius ameliorates hyperuricemia and renal injury in adenine/potassium oxonate-treated mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2024 (PubMed: 38879892) [IF=6.9]
4). circ0066187 promotes pulmonary fibrogenesis through targeting STAT3-mediated metabolism signal pathway. Cellular and molecular life sciences : CMLS, 2025 (PubMed: 39969586) [IF=6.2]

Application: WB    Species: Mouse    Sample:

Fig. 9 Integrative analysis of proteomics and metabolomics. A Venn diagram showed three pathways co-enriched in proteomics and metabolomics, including Protein digestion and absorption, PI3K-Akt signaling pathway, and FoxO signaling pathway. B Interaction network diagram of differential proteins and metabolites among the three pathways. C Western blot verified that DPP4, CCND1, CDK2, and FGF2 were up-regulated and COL6A1 and SOD2 were down-regulated in the TGF-β1-treated MRC-5 cells and BLM-induced mice. D l-Glutamine, l-proline, and AMP increased, and l-arginine, l-phenylalanine, l-lysine, and l-tryptophan decreased in the TGF-β1-treated MRC-5 cells and BLM-induced mice. E Western blot demonstrated that circ0066187 knockdown decreased DPP4, CCND1, CDK2, and FGF2 expression and increased COL6A1 and SOD2 expression compared with those in TGF-β1-treated group. Circ0066187 overexpression enhanced DPP4, CCND1, CDK2, and FGF2 expression, and decreased COL6A1 and SOD2 expression. F miR-29b-2-5p mimic enhanced COL6A1 and SOD2 expression and inhibited DPP4, CCND1, CDK2, and FGF2 expression. miR-29b-2-5p inhibitor enhanced DPP4, CCND1, CDK2, and FGF2 expression and inhibited COL6A1 and SOD2 expression. G Rescue experiment of Western blot demonstrated that the miR-29b-2-5p inhibitor reversed the downward trend of DPP4, CCND1, CDK2, and FGF2 and the upward trend of COL6A1 and SOD2 caused by si-circ0066187. miR-29b-2-5p mimic reversed the upward trend of DPP4, CCND1, CDK2, and FGF2 and the downward trend of COL6A1 and SOD2 caused by circ0066187 overexpression. H Western blot showed that si-STAT3 decreased DPP4, CCND1, CDK2, and FGF2 expression, and increased COL6A1 and SOD2 expression. Overexpressed STAT3 enhanced DPP4, CCND1, CDK2, and FGF2 expression and inhibited COL6A1 and SOD2 expression. I Rescue experiment showed that STAT3 overexpression reversed the downward trend of DPP4, CCND1, CDK2, and FGF2 and the upward trend of COL6A1 and SOD2 caused by si-circ0066187. si-STAT3 reversed the upward trend of DPP4, CCND1, CDK2, and FGF2 and the downward trend of COL6A1 and SOD2 caused by circ0066187 overexpression. NC represents negative control, BP represents blank plasmid, and RP represents the recombinant plasmid of overexpressed circ0066187. OE-STAT3 represents overexpressed STAT3. Each bar represents the mean ± SD; n = 6; *p 
5). Silica nanoparticles cause ovarian dysfunction and fertility decrease in mice via oxidative stress-activated autophagy and apoptosis. Ecotoxicology and environmental safety, 2024 (PubMed: 39303637) [IF=6.2]
6). Procyanidin B2 regulates the Sirt1/Nrf2 signaling pathway to improve random-pattern skin flap survival. Phytotherapy Research, 2023 (PubMed: 37128130) [IF=6.1]
7). Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway. Nutrients, 2022 (PubMed: 35807771) [IF=5.9]
8). 3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2. Journal of Agricultural and Food Chemistry, 2023 (PubMed: 37750480) [IF=5.7]
9). DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology, 2024 (PubMed: 38274803) [IF=5.7]
10). Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3. Acta physiologica (Oxford, England), 2024 (PubMed: 38752665) [IF=5.6]
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