产品: Heme oxygenase 2 抗体
货号: AF5143
描述: Rabbit polyclonal antibody to Heme oxygenase 2
应用: WB IHC
反应: Human, Mouse
预测: Pig, Bovine, Sheep, Dog
分子量: 36 kDa; 36kD(Calculated).
蛋白号: P30519
RRID: AB_2837629

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(82%), Bovine(83%), Sheep(83%), Dog(83%)
克隆:
Polyclonal
特异性:
Heme oxygenase 2 Antibody detects endogenous levels of total Heme oxygenase 2.
RRID:
AB_2837629
引用格式: Affinity Biosciences Cat# AF5143, RRID:AB_2837629.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; Heme oxygenase 2; HMOX 2; Hmox2; HMOX2 protein; HMOX2_HUMAN; HO 2; HO-2; HO2; OTTHUMP00000159847;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
描述:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
序列:
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Bovine
83
Sheep
83
Dog
83
Pig
82
Horse
75
Rabbit
67
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P30519 作为底物

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
S8 Phosphorylation
S14 Phosphorylation
K24 Ubiquitination
S34 Phosphorylation
K38 Ubiquitination
K55 Ubiquitination
K59 Ubiquitination
Y157 Phosphorylation
K176 Ubiquitination
K199 Ubiquitination
Y202 Phosphorylation
K216 Acetylation
K259 Ubiquitination
K264 Ubiquitination
Y268 Phosphorylation
S280 Phosphorylation
C282 S-Nitrosylation
T286 Phosphorylation
S295 Phosphorylation
Y314 Phosphorylation
Y315 Phosphorylation

研究背景

功能:

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

细胞定位:

Microsome. Endoplasmic reticulum.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the heme oxygenase family.

研究领域

· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Digestive system > Mineral absorption.

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