CD8 Antibody - #AF5126

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产品: CD8 抗体
货号: AF5126
描述: Rabbit polyclonal antibody to CD8
应用: WB IHC
文献验证: WB, IHC
反应: Human, Mouse, Rat
蛋白号: P01732
RRID: AB_2837612

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CD8 Antibody detects endogenous levels of total CD8.
RRID:
AB_2837612
引用格式: Affinity Biosciences Cat# AF5126, RRID:AB_2837612.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

alpha polypeptide (p32); CD8; CD8 antigen alpha polypeptide; CD8 antigen alpha polypeptide (p32); CD8a; CD8A antigen; CD8A molecule; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; Ly3; LYT3; MAL; OKT8 T cell antigen; OTTHUMP00000160760; OTTHUMP00000160764; OTTHUMP00000203528; OTTHUMP00000203721; p32; T cell antigen Leu2; T cell co receptor; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen; T8/Leu-2 T-lymphocyte differentiation antigen;

抗原和靶标

免疫原:

A synthesized peptide derived from human CD8, corresponding to a region within the internal amino acids.

基因/基因ID:
CD8A(925)
描述:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).   (View pathway)

· Human Diseases > Immune diseases > Primary immunodeficiency.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Immune system > T cell receptor signaling pathway.   (View pathway)

文献引用

1). Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite. Cancer cell, 2024 (PubMed: 38821061) [IF=48.8]
2). Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy. ACS nano, 2022 (PubMed: 35737477) [IF=15.8]
3). Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single-Cell Transcriptomic Data with MetaTF. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025 (PubMed: 40397381) [IF=15.1]
4). Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy. Biomaterials, 2023 (PubMed: 37506512) [IF=12.8]
5). Single-cell transcriptomics of peripheral blood reveals anti-tumor systemic immunity induced by oncolytic virotherapy. Theranostics, 2022 (PubMed: 36438484) [IF=12.4]
6). Dietary palmitoleic acid reprograms gut microbiota and improves biological therapy against colitis. Gut microbes, 2023 (PubMed: 37203220) [IF=12.2]
7). Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment. Journal of advanced research, 2025 (PubMed: 40518113) [IF=11.4]
8). Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment. Asian Journal of Pharmaceutical Sciences, 2022 (PubMed: 35582636) [IF=10.7]

Application: IF/ICC    Species: mouse    Sample: skin

Fig. 8| CHALT attenuates splenomegaly and immune cell recruitment in IMQ-induced skin. On Day 7, (A) the spleens were collected and photographed, and (B) the weight ratio of spleen/body was calculated. Immunfluorescence staining of (C) CD 4 and (E) CD 8 in the skin, and the relative amount of (D) CD 4 and (F) CD 8 was quantified (the normal group as the control).
9). Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation. Journal of nanobiotechnology, 2025 (PubMed: 40075499) [IF=10.6]
10). Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation. Journal of nanobiotechnology, 2025 (PubMed: 40075499) [IF=10.2]

Application: IF/ICC    Species: Mouse    Sample:

Fig. 7 In Vivo Experiments on C-GAP-Induced ICD in OSCC of C3H Mice. A Representative Images of Immunohistochemical Staining for γ-H2AX in Tumor Tissue from C3H Mice in Different Groups (n = 4). B Representative Images of Immunohistochemical Staining for HMGB1 in Tumor Tissue from C3H Mice in Different Groups (n = 4). C Representative Images of Immunofluorescence Staining for CD3e and CD8 in Tumor Tissue from C3H Mice in Different Groups (n = 4)
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