VEGFR3 Antibody - #AF4201

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产品: VEGFR3 抗体
货号: AF4201
描述: Rabbit polyclonal antibody to VEGFR3
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse
预测: Pig, Bovine, Sheep, Rabbit, Chicken
蛋白号: P35916
RRID: AB_2837585

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
VEGFR3 Antibody detects endogenous levels of total VEGFR3.
RRID:
AB_2837585
引用格式: Affinity Biosciences Cat# AF4201, RRID:AB_2837585.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EC 2.7.10.1; flt 4; FLT-4; FLT4; FLT41; Fms related tyrosine kinase 4; Fms-like tyrosine kinase 4; LMPH1A; PCL; Soluble VEGFR3 variant 1; Soluble VEGFR3 variant 2; Soluble VEGFR3 variant 3; Tyrosine protein kinase receptor FLT4; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; Vascular endothelial growth factor receptor 3 precursor; VEGF R3; VEGFR 3; VEGFR-3; VEGFR3; VGFR3_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human VEGFR3, corresponding to a region within C-terminal amino acids.

基因/基因ID:
FLT4(2324)
描述:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC

研究领域

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

文献引用

1). Anti-lymphangiogenesis for boosting drug accumulation in tumors. Signal transduction and targeted therapy, 2024 (PubMed: 38616190) [IF=40.8]
2). Matrix Stiffness of GelMA Hydrogels Regulates Lymphatic Endothelial Cells toward Enhanced Lymphangiogenesis. ACS applied materials & interfaces, 2024 (PubMed: 39352138) [IF=8.3]
3). METTL3 suppresses anlotinib sensitivity by regulating m6A modification of FGFR3 in oral squamous cell carcinoma. Cancer Cell International, 2022 (PubMed: 36167542) [IF=5.8]

Application: WB    Species: Human    Sample: OSCC

Fig. 1 Anlotinib targets FGFR3 and inhibits FGFR3 phosphorylation in OSCC. A and B The tyrosine kinase inhibitor (TKI) targets of anlotinib were assessed by quantitative real-time PCR (qRT-PCR) and western blotting. C The expression and phosphorylation levels of FGFR3 were detected in concentration gradient anlotinib treated in SCC9 and SCC25 cells using the western blotting
4). VEGF-B prevents chronic hyperglycemia-induced retinal vascular leakage by regulating the CDC42-ZO1/VE-cadherin pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024 (PubMed: 39215561) [IF=4.4]

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