GABBR1 Antibody - #DF4934

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产品: GABBR1 抗体
货号: DF4934
描述: Rabbit polyclonal antibody to GABBR1
应用: WB IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q9UBS5
RRID: AB_2837287

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
GABBR1 Antibody detects endogenous levels of total GABBR1.
RRID:
AB_2837287
引用格式: Affinity Biosciences Cat# DF4934, RRID:AB_2837287.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABBR1 3; GABBR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA) B receptor 1; Gamma-aminobutyric acid type B receptor subunit 1; Gb1; GPRC3A; Seven transmembrane helix receptor;

抗原和靶标

免疫原:

A synthesized peptide derived from human GABBR1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
GABBR1(2550)

研究领域

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Substance dependence > Morphine addiction.

· Organismal Systems > Nervous system > GABAergic synapse.

· Organismal Systems > Sensory system > Taste transduction.

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

文献引用

1). Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor. BIOMEDICINE & PHARMACOTHERAPY, 2019 (PubMed: 31634778) [IF=6.9]

Application: WB    Species: human    Sample: SKOV3 cells

Fig. 4. |The protein expression of E-cadherin, N-cadherin, GABAB1 and GABAB2 in SKOV3 cells treated with DDP or pinocembrin for 48 h which was evaluated by western blot. *P < 0.05 vs. control (no DDP and no pinocembrin). #P < 0.05 vs. 100 μM pinocembrin.
2). Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord. Frontiers in Cell and Developmental Biology, 2021 (PubMed: 33869168) [IF=4.6]

Application: WB    Species: rat    Sample: spinal cord

FIGURE 6 | Bilirubin increased GABAA receptor expression, GABA concentration, and GABAergic sIPSC in spinal cords. (A) GABAA receptor expression increased gradually in the spinal cord enlargement of BDL rats without changing GABAB receptor expression, and ondansetron reduced GABAA receptor expression.

Application: WB    Species: Rat    Sample: spinal cords

FIGURE 6 Bilirubin increased GABAA receptor expression, GABA concentration, and GABAergic sIPSC in spinal cords. (A) GABAA receptor expression increased gradually in the spinal cord enlargement of BDL rats without changing GABAB receptor expression, and ondansetron reduced GABAA receptor expression. (B) The quantitative analysis of GABAA receptor expression in the BDL rats. (C) Intrathecal administration of bilirubin increased GABAA receptor expression, and co-administration of bilirubin and ondansetron decreased it without changing GABAB receptor expression. (D) The quantitative analysis of GABAA receptor expression after intrathecal administration of bilirubin in normal rats. (E) SDHNs cultured with bilirubin showed increased GABAA receptor expression without changing GABAB receptor expression, ondansetron reversed GABAA receptor expression. (F) The quantitative analysis of GABAA receptor expression in SDHNs. (G) GABA concentration in CSF of BDL group was significantly higher than sham group, and ondansetron intervention reversed this change. (H) Intrathecal administration of bilirubin (1000 μM) increased GABA concentration in CSF significantly, whereas ondansetron could reverse it. *P < 0.05.
3). The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats. JOURNAL OF PAIN, 2017 (PubMed: 28323246) [IF=4.0]

Application: WB    Species: rat    Sample:

Fig. 1. Activation of GABAB receptors (GABABRs) alleviated cancer-induced bone pain (CIBP)-related behaviors

Application: IF/ICC    Species: rat    Sample:

Fig. 1. Activation of GABAB receptors (GABABRs) alleviated cancer-induced bone pain (CIBP)-related behaviors

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