产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4926, RRID:AB_2837279.
展开/折叠
Endothelin B Receptor Like Protein 2; Endothelin B receptor-like protein 2; ETBR LP 2; ETBR-LP-2; ETBR2_HUMAN; ETBRLP2; G protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1; Gpr37l1;
抗原和靶标
Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).
- O60883 G37L1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC
研究背景
G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
O-glycosylated.
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.
Cell membrane>Multi-pass membrane protein. Cell projection>Cilium membrane>Multi-pass membrane protein.
Note: Associates with the basal membrane of Bergmann glia cell primary cilia.
Expressed in primary cortical astrocytes (at protein level). Expressed in the central nervous system.
Interacts with the PTCH1 receptor.
The N-terminal region is required for constitutive signal transduction.
Belongs to the G-protein coupled receptor 1 family.
限制条款
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