ETV4 Antibody - #BF0482
产品: | ETV4 抗体 |
货号: | BF0482 |
描述: | Mouse monoclonal antibody to ETV4 |
应用: | WB ELISA |
反应: | Human |
分子量: | 54kDa; 54kD(Calculated). |
蛋白号: | P43268 |
RRID: | AB_2833650 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# BF0482, RRID:AB_2833650.
展开/折叠
Adenovirus E1A enhancer binding protein; Adenovirus E1A enhancer-binding protein; E1A F; E1A-F; ETS translocation variant 4; ets variant gene 4 (E1A enhancer binding protein E1AF); ETV4; ETV4_HUMAN; PEA3; PEA3 protein; PEAS3; Polyomavirus enhancer activator 3; Polyomavirus enhancer activator 3 homolog; Protein PEA3;
抗原和靶标
Purified recombinant fragment of human ETV4 expressed in E. Coli.
- P43268 ETV4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGPKGGYSY
翻译修饰 - P43268 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S73 | Phosphorylation | Uniprot | |
K96 | Sumoylation | Uniprot | |
S101 | Phosphorylation | Uniprot | |
S140 | Phosphorylation | Uniprot | |
S149 | Phosphorylation | Uniprot | |
K226 | Sumoylation | Uniprot | |
K260 | Sumoylation | Uniprot | |
K322 | Sumoylation | Uniprot | |
Y392 | Phosphorylation | Uniprot | |
S396 | Phosphorylation | Q15831 (STK11) | Uniprot |
Y416 | Phosphorylation | Uniprot | |
K441 | Sumoylation | Uniprot |
研究背景
Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.
Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.
Nucleus.
Belongs to the ETS family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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