Cytochrome P450 4A11/22 Antibody - #DF4749

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产品: Cytochrome P450 4A11/22 抗体
货号: DF4749
描述: Rabbit polyclonal antibody to Cytochrome P450 4A11/22
应用: WB IF/ICC
文献验证: WB
反应: Human
预测: Bovine, Dog
蛋白号: Q02928 | Q5TCH4
RRID: AB_2837103

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
Cytochrome P450 4A11/22 Antibody detects endogenous levels of total Cytochrome P450 4A11/22.
RRID:
AB_2837103
引用格式: Affinity Biosciences Cat# DF4749, RRID:AB_2837103.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CP4AB_HUMAN; CYP4A; Cyp4a1; Cyp4a10; CYP4A11; Cyp4a14; Cyp4a3; CYP4A7; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450 4A1; Cytochrome P450 4A10; Cytochrome P450 4A11; Cytochrome P450 4A14; Cytochrome P450 4A2; Cytochrome P450 4A3; Cytochrome P450 4A7; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase;

抗原和靶标

免疫原:

A synthesized peptide derived from human Cytochrome P450 4A11/22, corresponding to a region within the internal amino acids.

基因/基因ID:
CYP4A11(1579) | CYP4A22(284541)

研究领域

· Metabolism > Lipid metabolism > Fatty acid degradation.

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

文献引用

1). CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. International Journal of Molecular Medicine, 2020 (PubMed: 32124935) [IF=5.7]

Application: WB    Species: Human    Sample: HepG2 cells

Figure 2 Effects of FFA, clofibrate and HET0016 on Oil Red staining, TG and CYP4A11 synthesis in HepG2 cells. HepG2 cells were treated with FFA (1 mM), FFA + clofibrate (100 µM) or FFA + HET0016 (1 µM) solution for 24 h. (A) Lipid droplets in HepG2 cells were stained with Oil Red O. Scale bar, 200 µm. (B) The effects of these treatments on TG content in HepG2 cells was measured. (C) ALT and AST level in FFA-induced HepG2 cells. (D) The mRNA level of CYP4A11 was examined by reverse transcription-quantitative polymerase chain reaction. (E) The protein level of CYP4A11 was assessed by western blot analysis. The results are presented as the mean ± standard deviation. *P

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