| 产品: | CDC14A 抗体 |
| 货号: | DF4732 |
| 描述: | Rabbit polyclonal antibody to CDC14A |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 66 KD; 67kD(Calculated). |
| 蛋白号: | Q9UNH5 |
| RRID: | AB_2837083 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4732, RRID:AB_2837083.
展开/折叠
CDC 10; Cdc 14; Cdc 14A; Cdc 14A1; Cdc 14A2; CDC10 (cell division cycle 10, S. cerevisiae, homolog); CDC10; Cdc14; CDC14 cell division cycle 14 homolog A; CDC14 homolog A; Cdc14A1; Cdc14A2; Cell division cycle 14 homolog A; Cell division cycle 14, S. cerevisiae, homolog A; Cell division cycle 14A; Dual specificity protein phosphatase CDC 14A; Dual specificity protein phosphatase CDC14A; hCDC 14; hCDC14; OTTHUMP00000012653; OTTHUMP00000012654; OTTHUMP00000012655;
抗原和靶标
- Q9UNH5 CC14A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UNH5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K69 | Ubiquitination | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| K422 | Methylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| S453 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y591 | Phosphorylation | Uniprot |
研究背景
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle pole. Cytoplasm>Cytoskeleton>Spindle. Cell projection>Kinocilium. Cell projection>Stereocilium.
Note: Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity).
Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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