产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4683, RRID:AB_2837034.
展开/折叠
CTCL tumor antigen HD CL 09; CTCL-associated antigen HD-CL-09; Cutaneous T cell lymphoma tumor antigen HD CL 09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell derived protein kinase; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC A; hKFC-A; JIK; JNK/SAPK inhibitory kinase; JNK/SAPK-inhibitory kinase; Jun kinase inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine kinase; Serine/threonine-protein kinase TAO3; STE20 like kinase; TAO kinase 3; TAOK3; TAOK3_HUMAN; Thousand and one amino acid protein 3;
抗原和靶标
Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
- Q9H2K8 TAOK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H2K8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| Y103 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| T181 | Phosphorylation | Q9H2G2 (SLK) | Uniprot |
| Y183 | Phosphorylation | Q9H2G2 (SLK) | Uniprot |
| K260 | Ubiquitination | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Q13315 (ATM) | Uniprot |
| S331 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Q13315 (ATM) | Uniprot |
| S421 | Phosphorylation | Uniprot | |
| Y429 | Phosphorylation | Uniprot | |
| T437 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Q13315 (ATM) | Uniprot |
| S572 | Phosphorylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| T666 | Phosphorylation | Uniprot | |
| T745 | Phosphorylation | Uniprot | |
| S782 | Phosphorylation | Uniprot | |
| K817 | Ubiquitination | Uniprot | |
| K830 | Acetylation | Uniprot | |
| K855 | Ubiquitination | Uniprot | |
| Y897 | Phosphorylation | Uniprot |
研究背景
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.
Cytoplasm. Cell membrane>Peripheral membrane protein.
Note: Also localized to the peripheral cell membrane.
Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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