TAZ Antibody - #DF4653

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产品: TAZ 抗体
货号: DF4653
描述: Rabbit polyclonal antibody to TAZ
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
分子量: 43 KD, 53 kDa; 33kD(Calculated).
蛋白号: Q16635
RRID: AB_2837004

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
TAZ Antibody detects endogenous levels of total TAZ.
RRID:
AB_2837004
引用格式: Affinity Biosciences Cat# DF4653, RRID:AB_2837004.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Barth syndrome; Cardiomyopathy dilated 3A (X linked); EFE2; Endocardial fibroelastosis 2; Protein G4.5; Tafazzin; TAZ; TAZ protein; TAZ_HUMAN;

抗原和靶标

免疫原:
Uniprot:

Q16635(TAZ_HUMAN) >>Visit HPA database.

基因/基因ID:
TAZ(6901)
表达:
Q16635 TAZ_HUMAN:

High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

序列:
MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR

翻译修饰 - Q16635 作为底物

Site PTM Type Enzyme
K56 Ubiquitination
K135 Ubiquitination
K149 Acetylation
K160 Ubiquitination
K264 Ubiquitination

研究背景

功能:

Some isoforms may be involved in cardiolipin (CL) metabolism.

细胞定位:

Membrane>Single-pass membrane protein.

Cytoplasm.

Membrane>Single-pass membrane protein.

Membrane>Single-pass membrane protein.

Membrane>Single-pass membrane protein.

Cytoplasm.

Membrane>Single-pass membrane protein.

Cytoplasm.

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

蛋白家族:

The hydrophilic domain may serve as an exposed loop interacting with other proteins.

Belongs to the taffazin family.

研究领域

· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.

文献引用

1). Gallic acid from Terminalia chebula inhibited the growth of esophageal carcinoma cells by suppressing the Hippo signal pathway. Iranian Journal of Basic Medical Sciences (PubMed: 33235697) [IF=2.2]
2). FKN regulates macrophage activation in lupus nephritis via the Hippo signaling pathway. Research Square

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