产品: VTI1A 抗体
货号: DF4609
描述: Rabbit polyclonal antibody to VTI1A
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 23 KD; 25kD(Calculated).
蛋白号: Q96AJ9
RRID: AB_2836973

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 50ul RMB¥ 1250 现货
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 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(86%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(93%), Xenopus(86%)
克隆:
Polyclonal
特异性:
VTI1A Antibody detects endogenous levels of total VTI1A.
RRID:
AB_2836973
引用格式: Affinity Biosciences Cat# DF4609, RRID:AB_2836973.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

MMDS3; MVti1; SNARE Vti1a beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport through interaction with tSNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1 rp2; Vti1-rp2; Vti1a; VTI1A vesicle transport through interaction with t-SNAREs 1A; VTI1A_HUMAN; VTI1RP2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
序列:
MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRRIIQNRILLVILGIIVVITILMAITFSVRRH

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
93
Xenopus
86
Zebrafish
86
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q96AJ9 作为底物

Site PTM Type Enzyme
S3 Phosphorylation
K35 Ubiquitination
K43 Ubiquitination
S66 Phosphorylation
S76 Phosphorylation
K89 Ubiquitination
S91 Phosphorylation
Y95 Phosphorylation
S110 Phosphorylation
T122 Phosphorylation
Y136 Phosphorylation
T170 Phosphorylation
K176 Ubiquitination
S178 Phosphorylation
S213 Phosphorylation

研究背景

功能:

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

细胞定位:

Cytoplasmic vesicle. Golgi apparatus membrane>Single-pass type IV membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

蛋白家族:

Belongs to the VTI1 family.

研究领域

· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.

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