CCT6A Antibody - #DF4562

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产品: CCT6A 抗体
货号: DF4562
描述: Rabbit polyclonal antibody to CCT6A
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Sheep, Dog, Chicken
分子量: 60 KD; 58kD(Calculated).
蛋白号: P40227
RRID: AB_2836913

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
预测:
Bovine(100%), Sheep(%), Dog(%), Chicken(%)
克隆:
Polyclonal
特异性:
CCT6A Antibody detects endogenous levels of total CCT6A.
RRID:
AB_2836913
引用格式: Affinity Biosciences Cat# DF4562, RRID:AB_2836913.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Acute morphine dependence related protein 2; Amino acid transport defect complementing; CCT zeta 1; CCT zeta; CCT-zeta; CCT-zeta-1; CCT6; CCTZ; Chaperonin containing T complex subunit 6; Chaperonin containing TCP1 subunit 6A; Chaperonin containing TCP1 subunit 6A (zeta 1); Histidine transport regulator 3; HTR3; MGC126214; MGC126215; MoDP 2; MoDP-2; MoDP2; T complex protein 1 subunit zeta; T complex protein 1 zeta subunit; TCP 1 zeta; TCP-1-zeta; TCP1 zeta; TCP20; TCPZ; TTCP20;

抗原和靶标

免疫原:
Uniprot:

P40227(TCPZ_HUMAN) >>Visit HPA database.

基因/基因ID:
CCT6A(908)
序列:
MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Chicken
100
Xenopus
70
Zebrafish
70
Pig
0
Horse
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

功能:

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin (Probable).

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.

蛋白家族:

Belongs to the TCP-1 chaperonin family.

文献引用

1). CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production. Journal of molecular cell biology, 2024 (PubMed: 38760881) [IF=5.3]

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