产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4538, RRID:AB_2836889.
展开/折叠
ATG24B; SNX 4; snx4; SNX4_HUMAN; Sorting nexin 4; Sorting nexin-4;
抗原和靶标
- O95219 SNX4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95219 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| C172 | S-Nitrosylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K205 | Methylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| T210 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| R247 | Methylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| T347 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| K356 | Methylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K449 | Ubiquitination | Uniprot |
研究背景
Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.
Early endosome. Early endosome membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC).
Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2. Interacts with BIN1.
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Belongs to the sorting nexin family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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