产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4527, RRID:AB_2836878.
展开/折叠
AT1A2_HUMAN; Atp1a2; FHM2; KIAA0778; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ ATPase alpha 2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; Sodium/potassium-transporting ATPase subunit alpha-2;
抗原和靶标
- P50993 AT1A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50993 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y9 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| Y539 | Phosphorylation | Uniprot | |
| T570 | Phosphorylation | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| K602 | Ubiquitination | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| T614 | Phosphorylation | Uniprot | |
| T620 | Phosphorylation | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| T637 | Phosphorylation | Uniprot | |
| K695 | Ubiquitination | Uniprot | |
| S719 | Phosphorylation | Uniprot | |
| K723 | Ubiquitination | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| K830 | Ubiquitination | Uniprot | |
| K840 | Ubiquitination | Uniprot | |
| R845 | Methylation | Uniprot | |
| T904 | Phosphorylation | Uniprot | |
| Y905 | Phosphorylation | Uniprot | |
| S940 | Phosphorylation | Uniprot | |
| K947 | Ubiquitination | Uniprot | |
| K949 | Ubiquitination | Uniprot |
研究背景
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.
· Organismal Systems > Digestive system > Protein digestion and absorption.
· Organismal Systems > Digestive system > Mineral absorption.
限制条款
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