SCN4A Antibody - #DF4513

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产品: SCN4A 抗体
货号: DF4513
描述: Rabbit polyclonal antibody to SCN4A
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P35499
RRID: AB_2836864

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SCN4A Antibody detects endogenous levels of total SCN4A.
RRID:
AB_2836864
引用格式: Affinity Biosciences Cat# DF4513, RRID:AB_2836864.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HYKPP; HYPP; Na(V)1.4; NAC1A; Nav1.4; Scn4a; SCN4A_HUMAN; Skeletal muscle voltage dependent sodium channel type IV alpha subunit; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel voltage gated type IV alpha subunit; Voltage gated sodium channel subunit alpha Nav1.4; Voltage gated sodium channel type 4 alpha; Voltage-gated sodium channel subunit alpha Nav1.4;

抗原和靶标

免疫原:

A synthesized peptide derived from human SCN4A, corresponding to a region within the internal amino acids.

基因/基因ID:
SCN4A(6329)

文献引用

1). Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Macrophage Polarization-Related Genes. Journal of hepatocellular carcinoma, 2024 (PubMed: 38751862) [IF=4.1]

Application: IHC    Species: Human    Sample:

Figure 9 SCN4A is highly expressed in HCC tissues (A) MPRGs expressions in HCC of TCGA-HCC dataset. (B) qPCR result of SCN4A expressions in HCC of patients. (C) Representative IHC staining of SCN4A expressions in HCC of patients. Bars=100 μm.

Application: WB    Species: Human    Sample: HCC cells

Figure 10 SCN4A expression in HCC cells could regulate M2 macrophage polarization in HCC tumor microenvironment and HCC progression (A) THP-1 cells were induced to differentiate into macrophages displaying M2 polarization by treatment with IL-4 (20 ng/mL) and IL-13 (20 ng/mL), in the presence of PMA (100 ng/mL). (B) Schematic of the indirect co-culture model. (C) qPCR result of CD163 expression in MP macrophages of the indirect co-culture model. (D) CCK-8 experiments showed the growth curve of HepG2 cells. (E) Colony formation assay showed the growth of HepG2 cells. (F)Western blot analysis of SCN4A, β-catenin, c-Myc, CyclinD1, NOTCH-1, HIF-1α, VEGFA, Vimentin, N-Cadherin and E-Cadherin in HepG2 cells. **** P < 0.0001.

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