产品: PPP2R3C 抗体
货号: DF4486
描述: Rabbit polyclonal antibody to PPP2R3C
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Zebrafish, Rabbit
分子量: 53 KD; 53kD(Calculated).
蛋白号: Q969Q6
RRID: AB_2836837

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 50ul RMB¥ 1250 现货
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(83%), Rabbit(100%)
克隆:
Polyclonal
特异性:
PPP2R3C Antibody detects endogenous levels of total PPP2R3C.
RRID:
AB_2836837
引用格式: Affinity Biosciences Cat# DF4486, RRID:AB_2836837.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C14orf10; Chromosome 14 open reading frame 10; G4-1; G5pr; Hypothetical protein FLJ20644; P2R3C_HUMAN; ppp2r3c; protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma; protein phosphatase 2, regulatory subunit B'', gamma; Protein phosphatase subunit G5PR; rhabdomyosarcoma antigen MU-RMS-40.6A; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C; rhabdomyosarcoma antigen Mu-RMS-40.6C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q969Q6 P2R3C_HUMAN:

Ubiquitously expressed in brain and other tissues.

序列:
MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSENSADLDDT

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Rabbit
100
Zebrafish
83
Horse
78
Bovine
78
Sheep
78
Dog
78
Pig
0
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q969Q6 作为底物

Site PTM Type Enzyme
K54 Ubiquitination
T55 Phosphorylation
Y60 Phosphorylation
K73 Ubiquitination
S178 Phosphorylation
Y180 Phosphorylation
K295 Ubiquitination
K341 Ubiquitination

研究背景

功能:

May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells (By similarity).

细胞定位:

Nucleus. Cytoplasm.
Note: Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitously expressed in brain and other tissues.

亚基结构:

Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

研究领域

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Genetic Information Processing > Translation > mRNA surveillance pathway.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Nervous system > Dopaminergic synapse.

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