| 产品: | ZFYVE20 抗体 |
| 货号: | DF4373 |
| 描述: | Rabbit polyclonal antibody to ZFYVE20 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 89 KD; 89kD(Calculated). |
| 蛋白号: | Q9H1K0 |
| RRID: | AB_2836661 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4373, RRID:AB_2836661.
展开/折叠
110 kDa protein; FYVE finger containing Rab5 effector protein Rabenosyn 5; FYVE finger-containing Rab5 effector protein rabenosyn-5; Rabenosyn-5; RBNS5_HUMAN; Zfyve20; zinc finger FYVE domain containing 20; Zinc finger FYVE domain-containing protein 20;
抗原和靶标
- Q9H1K0 RBNS5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVASLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVWSGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKEYNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPFEMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQKGGTD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H1K0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S217 | Phosphorylation | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| T378 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| Y496 | Phosphorylation | Uniprot | |
| T501 | Phosphorylation | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| T588 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S684 | Phosphorylation | Uniprot | |
| K773 | Ubiquitination | Uniprot |
研究背景
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane.
Cell membrane>Lipid-anchor>Cytoplasmic side. Early endosome membrane>Lipid-anchor.
Note: Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.
Interacts with EHD1, RAB4A, RAB5A, RAB14, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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