GNL3L Antibody - #DF4113
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| 产品: | GNL3L 抗体 |
| 货号: | DF4113 |
| 描述: | Rabbit polyclonal antibody to GNL3L |
| 应用: | WB IF/ICC |
| 反应: | Human, Monkey |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 66 KD; 66kD(Calculated). |
| 蛋白号: | Q9NVN8 |
| RRID: | AB_2836404 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4113, RRID:AB_2836404.
展开/折叠
FLJ10613; Guanine nucleotide binding protein-like 3 (nucleolar)-like; novel GTPase; OTTHUMP00000023374;
抗原和靶标
- Q9NVN8 GNL3L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NVN8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K20 | Sumoylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K62 | Sumoylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K200 | Methylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| K375 | Sumoylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| K469 | Ubiquitination | Uniprot | |
| K477 | Sumoylation | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| K482 | Sumoylation | Uniprot | |
| K482 | Ubiquitination | Uniprot | |
| Y489 | Phosphorylation | Uniprot | |
| K502 | Acetylation | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| S513 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | Uniprot |
研究背景
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Nucleus>Nucleolus.
Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.
In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
Belongs to the TRAFAC class YlqF/YawG GTPase family.
研究领域
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
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