(3)
(4)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3971, RRID:AB_2836324.
展开/折叠
CCS; CCS_HUMAN; Copper chaperone for superoxide dismutase; MGC138260; SOD 4; SOD4; Superoxide dismutase copper chaperone; Superoxide Dismutase 4;
抗原和靶标
- O14618 CCS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14618 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K76 | Ubiquitination | Uniprot | |
| R165 | Methylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| R209 | Methylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| S267 | Phosphorylation | Uniprot |
研究背景
Delivers copper to copper zinc superoxide dismutase (SOD1).
Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
Cytoplasm.
Ubiquitous.
Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4.
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
研究领域
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
文献引用
Application: WB Species: human Sample: lens capsule
限制条款
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