PDE4C Antibody - #DF3872

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产品: PDE4C 抗体
货号: DF3872
描述: Rabbit polyclonal antibody to PDE4C
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Dog
蛋白号: Q08493
RRID: AB_2836225

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PDE4C Antibody detects endogenous levels of total PDE4C.
RRID:
AB_2836225
引用格式: Affinity Biosciences Cat# DF3872, RRID:AB_2836225.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

5''-cyclic phosphodiesterase 4C; cAMP specific 3' 5' cyclic phosphodiesterase 4C; cAMP-specific 3''; DPDE 1; DPDE1; MGC126222; PDE 21; PDE 4C; PDE21; Pde4c; PDE4C_HUMAN; Phosphodiesterase 4C; Phosphodiesterase 4C cAMP specific; Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila); Phosphodiesterase E1 dunce homolog; Phosphodiesterase E1 dunce homolog Drosophila; Phosphodiesterase type 4C;

抗原和靶标

免疫原:

A synthesized peptide derived from human PDE4C, corresponding to a region within the internal amino acids.

基因/基因ID:
PDE4C(5143)

研究领域

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Morphine addiction.

· Metabolism > Nucleotide metabolism > Purine metabolism.

文献引用

1). Analysis of the effects of M2 macrophage-derived PDE4C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma. Journal of cellular and molecular medicine, 2024 (PubMed: 38774995) [IF=5.3]

Application: IHC    Species: human    Sample:

FIGURE 5 TAM-derived gene PDE4C was associated metastasis in OS patients. (A) Heatmap exhibited the metastasis condition, M2 macrophage, PDE4C expression in OS from TARGET cohort. (B) Metastasis state between OS patients in high M2 macrophage and low M2 macrophage group from TARGET cohort. (C) Metastasis state between OS patients in high PDE4C and low PDE4C group from TARGET cohort. (D) Diagnostic value of M2 macrophage and PDE4C level for predicting metastasis in OS patients from TARGET cohort. (E) Heatmap exhibited the metastasis condition, M2 macrophage, PDE4C expression in OS from research cohort. (F) Metastasis state between OS patients in high M2 macrophage and low M2 macrophage group from research cohort. (G) Metastasis state between OS patients in high PDE4C and low PDE4C group from research cohort. (H) Diagnostic value of M2 macrophage and PDE4C level for predicting metastasis in OS patients from research cohort. (I and J) IHC was performed to detect the protein levels of PDE4C in OS tissues with and without metastasis. (K) Expression relationship between PDE4C mRNA levels and protein levels. *p 

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