SLC27A5 Antibody - #DF3845

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产品: SLC27A5 抗体
货号: DF3845
描述: Rabbit polyclonal antibody to SLC27A5
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Bovine, Horse
蛋白号: Q9Y2P5
RRID: AB_2836202

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SLC27A5 Antibody detects endogenous levels of total SLC27A5.
RRID:
AB_2836202
引用格式: Affinity Biosciences Cat# DF3845, RRID:AB_2836202.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ACSB; ACSVL6; BA CoA ligase; BA-CoA ligase; BACS; BAL; Bile acid CoA ligase; Bile acid-CoA ligase; Bile acyl CoA synthetase; Bile acyl-CoA synthetase; Cholate CoA ligase; Cholate--CoA ligase; FACVL3; FATP 5; FATP-5; FATP5; Fatty acid Coenzyme A ligase very long chain 3; Fatty acid transport protein 5; Fatty-acid-coenzyme A ligase; FLJ22987; S27A5_HUMAN; Slc27a5; Solute carrier family 27 (fatty acid transporter) member 5; Solute carrier family 27 member 5; Very long chain acyl CoA synthetase homolog 2; Very long chain acyl CoA synthetase related protein; very long-chain 3; Very long-chain acyl-CoA synthetase homolog 2; Very long-chain acyl-CoA synthetase-related protein; VLACS related; VLACS-related; VLACSR; VLCS H2; VLCS-H2; VLCSH2;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC27A5, corresponding to a region within the internal amino acids.

基因/基因ID:
SLC27A5(10998)

研究领域

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Metabolism > Lipid metabolism > Primary bile acid biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > PPAR signaling pathway.

文献引用

1). B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36. Cell death & disease, 2022 (PubMed: 35436984) [IF=8.1]

Application: WB    Species: Mouse    Sample:

Fig. 5: Overexpression of BCL6 hampers CD36 expression both in vivo and in vitro. Relative mRNA levels of genes related to (A) FFA oxidation, (B) synthesis, and (C) uptake in the livers of AAV-Control mice and the AAV-BCL6 mice fed an HFD for 16 weeks. D Protein level of BCL6 and genes related to FFA uptake in the livers of mice. Relative mRNA levels of gene related to (E) FFA oxidation, (F) synthesis and G uptake in the livers of AAV-Control mice and the AAV-BCL6 mice fed an HFD for 16 weeks. D Protein level of BCL6 and genes related to FFA uptake in the livers of mice. Relative mRNA levels of gene related to (E) FFA oxidation, (F) synthesis, and (G) uptake in the LO2 cells stimulated with PA (0.3 mM) for 24 h after transfected with Ad-GFP or Ad-BCL6 for 48 h. n = 3 in each group. H Protein level of BCL6 and genes related to FFA uptake in the LO2 cells. Data represent the mean ± SEM, *P 
2). Norepinephrine inhibits CD8+ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma. British journal of cancer, 2023 (PubMed: 36646807) [IF=6.4]

Application: WB    Species: human    Sample: LUAD cells

Fig. 5: Norepinephrine (NE) regulates the secretion of CXCL9 and adenosine (ADO) by WNT7A/β-catenin signalling in lung adenocarcinoma (LUAD) cells. a The KEGG pathway enrichment analysis of the differentially expressed genes (DEGs); b the GSEA between the NE and the control (NC) groups; c the volcano plots of the DEGs; d the expression levels of Wnt1, Wnt2, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt7a and Wnt10a in the tumour tissues of the anti-PD-1 mAb + Vehicle and NE + anti-PD-1 mAb + Vehicle groups; e western blotting confirmed the efficiency of WNT7A silencing; f downregulation of WNT7A by shRNA significantly antagonised NE-induced β-catenin, CD39 and CD73 expression, as well as NE-inhibited CXCL9 expression in LUAD cells; g downregulation of β-catenin by shRNA greatly antagonised NE/WNT7A-induced CD39 and CD73 expression, as well as NE/WNT7A-inhibited CXCL9 expression in LUAD cells; h the β-catenin expression level in tumours was detected in the anti-PD-1 mAb + vehicle group and anti-PD-1 mAb+NE + vehicle group using immunohistochemistry. *P 
3). Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma. Frontiers in Molecular Biosciences, 2022 (PubMed: 35155561) [IF=5.0]
4). Identification of key genes associated with the progression of liver fibrosis to hepatocellular carcinoma based on iTRAQ proteomics and GEO database. Annals of hepatology, 2022 (PubMed: 35124283) [IF=3.7]

Application: WB    Species: human    Sample:

Fig. 8. The expression and survival analysis of ALDH2, SLC27A5 and ASNS in patients with HCC and validation. (A) The expression of ALDH2, SLC27A5 and ASNS in HCC. (B) The expression of ALDH2, SLC27A5 and ASNS in different stages of HCC. (C) Survival analysis of ALDH2, SLC27A5 and ASNS. (D) WB analysis of ALDH2, SLC27A5 and ASNS. (E) qRT-PCR analysis of ALDH2, SLC27A5 and ASNS.

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