| 产品: | APBA3 抗体 |
| 货号: | DF3768 |
| 描述: | Rabbit polyclonal antibody to APBA3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Rat |
| 分子量: | 61 KD; 61kD(Calculated). |
| 蛋白号: | O96018 |
| RRID: | AB_2836132 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3768, RRID:AB_2836132.
展开/折叠
Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta A4 precursor protein-binding family A member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; APBA3_HUMAN; lin 10; MGC:15815; Mint 3; Mint-3; Neuron specific X11L2 protein; Neuron-specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; Neuronal Munc18-1-interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2;
抗原和靶标
A synthesized peptide derived from human APBA3, corresponding to a region within N-terminal amino acids.
- O96018 APBA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL
研究背景
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Cytoplasm>Perinuclear region.
Expressed in all tissues examined with lower levels in brain and testis.
Binds to the cytoplasmic domain of amyloid protein (APP) in vivo. Interacts with HIF1AN (via N-terminus). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN.
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
限制条款
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