产品: MLANA 抗体
货号: AF0204
描述: Rabbit polyclonal antibody to MLANA
应用: WB IHC IF/ICC
反应: Human, Mouse
分子量: 15kDa; 13kD(Calculated).
蛋白号: Q16655
RRID: AB_2833288

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
MLANA Antibody detects endogenous levels of total MLANA.
RRID:
AB_2833288
引用格式: Affinity Biosciences Cat# AF0204, RRID:AB_2833288.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q16655 MAR1_HUMAN:

Expression is restricted to melanoma and melanocyte cell lines and retina.

描述:
MLANA Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein SILV/PMEL17, which is critical to the formation of stage II melanosomes. Interacts with SILV/PMEL17.
序列:
MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP

翻译修饰 - Q16655 作为底物

Site PTM Type Enzyme
S87 Phosphorylation
Y104 Phosphorylation
S108 Phosphorylation
Y116 Phosphorylation

研究背景

功能:

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

翻译修饰:

Acylated.

细胞定位:

Endoplasmic reticulum membrane>Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane. Melanosome.
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expression is restricted to melanoma and melanocyte cell lines and retina.

亚基结构:

Interacts with PMEL. Interacts with GPR143.

文献引用

1). The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin. Journal of experimental & clinical cancer research : CR, 2021 (PubMed: 34470658) [IF=11.3]

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