Cytochrome P450 4Z1 Antibody - #DF3590

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产品: Cytochrome P450 4Z1 抗体
货号: DF3590
描述: Rabbit polyclonal antibody to Cytochrome P450 4Z1
应用: WB IHC IF/ICC
文献验证: IF/ICC
反应: Human, Mouse, Rat
分子量: 59 KD; 59kD(Calculated).
蛋白号: Q86W10
RRID: AB_2835962

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Cytochrome P450 4Z1 Antibody detects endogenous levels of total Cytochrome P450 4Z1.
RRID:
AB_2835962
引用格式: Affinity Biosciences Cat# DF3590, RRID:AB_2835962.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CP4Z1_HUMAN; CYP4A20; CYP4Z1; CYPIVZ1; Cytochrome P450 4Z1; Cytochrome P450 family 4 subfamily Z polypeptide 1;

抗原和靶标

免疫原:
Uniprot:

Q86W10(CP4Z1_HUMAN) >>Visit HPA database.

基因/基因ID:
CYP4Z1(199974)
表达:
Q86W10 CP4Z1_HUMAN:

Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.

序列:
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC

研究背景

细胞定位:

Endoplasmic reticulum membrane>Single-pass type II membrane protein. Microsome membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.

蛋白家族:

Belongs to the cytochrome P450 family.

文献引用

1). Concomitant occurence of multiple autoantibodies against human cytochromes P450. International Immunopharmacology, 2021 (PubMed: 34464888) [IF=4.8]
2). Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans. International Immunopharmacology, 2019 (PubMed: 31082724) [IF=4.8]

Application: IF/ICC    Species: human    Sample: MCF-7 or MCF-10A cells

Fig. 2.| Detection of CYP4Z1 on the outer surface of non-permeabilized MCF-7 or MCF-10A cells by rabbit anti-CYP4Z1 IgG and goat anti-rabbit IgG conjugated to Alexa fluor 488. The non-permeabilized cells were probed with antibodies and stained with DAPI and Deep Red plasma membrane stain as indicated. Magnification is×1,000 for all images
3). Involvement of WNT2 in trophoblast cell behavior in preeclampsia development. CELL CYCLE, 2020 (PubMed: 32779546) [IF=3.4]
4). Upregulation of estrogen receptor alpha (ERα) expression in transgenic mice expressing human CYP4Z1. Breast Cancer Research and Treatment, 2021 (PubMed: 34725776) [IF=3.0]

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