THRB Antibody - #AF0357

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产品: THRB 抗体
货号: AF0357
描述: Rabbit polyclonal antibody to THRB
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Dog
蛋白号: P00734
RRID: AB_2833522

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC: 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
THRB Antibody detects endogenous levels of total THRB.
RRID:
AB_2833522
引用格式: Affinity Biosciences Cat# AF0357, RRID:AB_2833522.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

coagulation factor II (thrombin); Coagulation factor II; F2; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain;

抗原和靶标

免疫原:

A synthesized peptide derived from human THRB, corresponding to a region within the internal amino acids.

基因/基因ID:
F2(2147)
描述:
prothrombin Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Belongs to the peptidase S1 family.

研究领域

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Ginsenoside CK targets PHD2 to prevent platelet adhesion and enhance blood circulation by modifying the three-dimensional arrangement of collagen. Acta pharmaceutica Sinica. B, 2025 (PubMed: 40370536) [IF=14.7]
2). Multi-omics analysis reveals the pre-protective mechanism of Dendrobium flexicaule polysaccharide against alcohol-induced gastric mucosal injury. International journal of biological macromolecules, 2025 (PubMed: 39730050) [IF=7.7]
3). Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025 (PubMed: 39826283) [IF=6.7]
4). Development of a necroptosis-related prognostic model for uterine corpus endometrial carcinoma. Scientific reports, 2024 (PubMed: 38383747) [IF=3.8]

Application: WB    Species: Human    Sample: tumor tissues

Figure 5 Immune Infiltration analyse of TICs and identification of prognostic target gene in UCEC. (A) Bar chart depicted the composition of immune cells in each sample from the TCGA-UCEC cohort. (B) Violin plot illustrated the differential infiltration of 22 types of TICs. (C) Venn diagram presented 11 immune-related target genes. (D) Survival analysis demonstrated a significant impact of the THRB gene on prognosis (P 
5). KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer. Frontiers in Bioscience - Elite, 2023 (PubMed: 36722273)

Application: WB    Species: Human    Sample: thyroid papillary carcinoma cells

Fig. 3. The mechanism of KMT2D on papillary thyroid carcinoma cells. (a) ChIP assay. (b) qRT-PCR analysis. (c) Western blotting analysis. A, si-NC; B, si-KMT2D (1); C, si- KMT2D (1).

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