| 产品: | EID1 抗体 |
| 货号: | DF3489 |
| 描述: | Rabbit polyclonal antibody to EID1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 21 KD; 21kD(Calculated). |
| 蛋白号: | Q9Y6B2 |
| RRID: | AB_2835851 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3489, RRID:AB_2835851.
展开/折叠
21 kDa pRb associated protein; 21 kDa pRb-associated protein; C15orf3; CBP; Chromosome 15 open reading frame 3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI 1; CRI1; E1A like inhibitor of differentiation; E1A-like inhibitor of differentiation 1; EID 1; EID-1; EID1; EID1_HUMAN; EP300 interacting inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; IRO45620; MGC138883; MGC138884; NB4 apoptosis related protein; PNAS 22; PNAS22; PTD014; Rb and p300 binding protein EID 1; Rb and p300 binding protein EID1; RBP21; Retinoblastoma protein associated protein;
抗原和靶标
Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
- Q9Y6B2 EID1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEMAELSELYEESSDLQMDVMPGEGDLPQMEVGSGSRELSLRPSRSGAQQLEEEGPMEEEEAQPMAAPEGKRSLANGPNAGEQPGQVAGADFESEDEGEEFDDWEDDYDYPEEEQLSGAGYRVSAALEEADKMFLRTREPALDGGFQMHYEKTPFDQLAFIEELFSLMVVNRLTEELGCDEIIDRE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.
Nucleus. Cytoplasm.
Note: May shuttle between nucleus and cytoplasm.
Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.
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